Document Detail

Murine models for mycobacterioses.
MedLine Citation:
PMID:  3317615     Owner:  NLM     Status:  MEDLINE    
Murine models have proven very useful in studying the pathobiology and chemotherapy of a number of mycobacterioses. While there are a number of significant variations from the human model, a substantial body of experience aids in extrapolating from the murine model to the human condition. The most extensively studied infection is Mycobacterium tuberculosis. However, there have been significant advances recently using the Beige mouse (an immunodeficient mutant) as an acute infection model for disease due to Mycoba avium complex. Less extensively studied have been Mycobacterium kansasii, Mycobacterium fortuitum, and Mycobacterium chelonei, the other relatively common nontuberculous mycobacterioses involving man.
P R Gangadharam
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in respiratory infections     Volume:  1     ISSN:  0882-0546     ISO Abbreviation:  Semin Respir Infect     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1988-01-19     Completed Date:  1988-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8700961     Medline TA:  Semin Respir Infect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-61     Citation Subset:  IM; X    
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
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MeSH Terms
Disease Models, Animal
Mycobacterium Infections, Atypical / drug therapy
Mycobacterium avium
Tuberculosis, Pulmonary / drug therapy*
Grant Support

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