Document Detail

Murine models for antiretroviral therapy.
MedLine Citation:
PMID:  2540110     Owner:  NLM     Status:  MEDLINE    
Rauscher murine leukemia virus (RLV) infection of adult mice results in splenomegaly that is proportional to the virus titer. We have used this model to study the therapy of chronic viremia as well as chemoprophylaxis after viral exposure, both with single agents and with combination therapy. We showed that prompt initiation of effective antiviral therapy after viral exposure can prevent de novo infection. We have also developed a murine neurotropic retrovirus model which allows analysis of candidate antiviral agents for activity across the blood-brain barrier. This model can also be used to study therapeutic approaches to retroviral infections acquired at midgestation or during the neonatal period.
R M Ruprecht
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Intervirology     Volume:  30 Suppl 1     ISSN:  0300-5526     ISO Abbreviation:  Intervirology     Publication Date:  1989  
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0364265     Medline TA:  Intervirology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  2-11     Citation Subset:  IM; X    
Dana-Farber Cancer Institute, Boston, Mass. 02115.
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MeSH Terms
Acquired Immunodeficiency Syndrome / drug therapy
Combined Modality Therapy
Disease Models, Animal*
Drug Evaluation, Preclinical
Interferon Type I, Recombinant / therapeutic use
Leukemia Virus, Murine / drug effects
Leukemia, Experimental / drug therapy*,  prevention & control,  therapy
Mice, Inbred BALB C*
Rauscher Virus / drug effects
Retroviridae / drug effects
Retroviridae Infections / drug therapy*,  prevention & control,  therapy
Viremia / drug therapy,  prevention & control,  therapy
Zidovudine / therapeutic use*
Grant Support
Reg. No./Substance:
0/Interferon Type I, Recombinant; 30516-87-1/Zidovudine

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