Document Detail

Murine leukemia virus-associated cell surface antigens in rats neonatally infected with Gross murine leukemia virus.
MedLine Citation:
PMID:  292817     Owner:  NLM     Status:  MEDLINE    
The inoculation of newborn W/F, Lew, AS and DA rats with Gross murine leukemia virus (G-MuLV) resulted in the prompt appearance of cells with viral protein antigens (VPA) on their surfaces. These were first found in the bone marrow and spleen and later in the thymus gland. As the animals developed, the VPA-positive population expanded and the intensity of the fluorescence increased. In the spleen, the cells with the strongest fluorescence had the properties of T-cells, but in both spleen and bone marrow low levels of VPA were found on non-T-cells. The VPA-positive population expanded long before malignant cells could be detected and, in most animals, the entire T-cell compartment became antigen-positive. These animals were unable to respond to G-MuLV antigens and many eventually developed leukemia. However, some animals apparently broke the tolerance that followed neonatal infection and eliminated VPA-positive cells from their tissues
R S Basch; D Grausz; N Harris; N A Mitchison
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  63     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-02-15     Completed Date:  1980-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1485-92     Citation Subset:  IM    
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MeSH Terms
AKR murine leukemia virus / immunology*
Animals, Newborn
Antigens, Neoplasm*
Antigens, Surface*
Antigens, Viral*
Immune Tolerance
Immunity, Cellular
Leukemia, Experimental / immunology*
Rats, Inbred Strains
Spleen / immunology
Thymus Gland / immunology
Tumor Virus Infections / immunology*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Antigens, Viral

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