| Murine cytomegalovirus myocarditis. | |
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MedLine Citation:
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PMID: 1655454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Murine cytomegalovirus infects a variety of organs after inoculation into adult male mice. We have established a model of myocarditis in which focal lesions from adjacent to virus-infected endothelial cells. The development of the myocarditis is mediated by CD4+ helper T cells. The lesions fail to develop when these cells are eliminated from the animal by administration of a specific monoclonal antibody. Alternatively, repletion of thymectomized, irradiated and bone-marrow reconstituted animals with CD4+ cells results in myocarditis. The evidence, although incomplete, suggests that a delayed hypersensitivity response is the pathogenetic mechanism involved. |
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Authors:
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J E Craighead; S A Huber; W B Martin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European heart journal Volume: 12 Suppl D ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-11-08 Completed Date: 1991-11-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 69-72 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Vermont College of Medicine, Burlington 05405. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / immunology Antigens, CD4 / immunology Cytomegalovirus / immunology Cytomegalovirus Infections / immunology* Disease Models, Animal Hypersensitivity, Delayed / immunology Male Mice Mice, Inbred BALB C Myocarditis / immunology, microbiology* T-Lymphocytes, Helper-Inducer / immunology |
| Grant Support | |
ID/Acronym/Agency:
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HL RO1 41502/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, CD4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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