Document Detail

Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone.
MedLine Citation:
PMID:  17853187     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In rats, maternal low protein diet induces growth restriction, increases fetal glucocorticoid exposure and programs cardiovascular and endocrine dysfunction in adult offspring. We hypothesized that both maternal low protein diet and late gestation dexamethasone program murine offspring to develop hypertension, vascular dysfunction, and glucose intolerance.
METHODS: An iso-caloric low protein diet (LP) was provided to dams from E0 to E19. Additional dams received a normal protein diet without (NP) or with either dexamethasone (NP-Dex, 0.1 mg/kg/d sc) or normal saline (NP-NS) from E10 to E18.
RESULTS: Offspring of dams given LP weighed less at 10 days than NP offspring, while Dex administration did not alter pup weight. At 4 months, all four groups had similar systolic blood pressures and no detectable differences were evoked by oral L-NAME. Offspring of LP mice had impaired glucose clearance that was directly correlated with their weight at 10 days. Aortic rings from offspring of both LP and NP-Dex exposed dams had impaired vasodilatation to acetylcholine.
CONCLUSIONS: These findings demonstrate that both maternal low protein diet and late gestation dexamethasone program murine offspring to develop endothelial dysfunction in the absence of hypertension, while only maternal LP impaired perinatal growth and glucose clearance in adult offspring.
KEYWORDS: Acetylcholine; blood pressure; developmental biology; fetal programming
Robert D Roghair; Jeffrey L Segar; Robert A Kilpatrick; Emily M Segar; Thomas D Scholz; Fred S Lamb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  20     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-01-31     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  833-41     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Blood Pressure / drug effects
Dexamethasone / pharmacology*
Diet, Protein-Restricted / adverse effects*
Disease Models, Animal
Endothelium / drug effects,  physiopathology
Fetal Development / drug effects*
Glucocorticoids / pharmacology*
Glucose Tolerance Test
Prenatal Exposure Delayed Effects
Reg. No./Substance:
0/Glucocorticoids; 7S5I7G3JQL/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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