Document Detail


Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial.
MedLine Citation:
PMID:  22467697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a painful condition of unknown etiology, affecting more than 2.5 billion people worldwide. Vitamin deficiencies have been implicated as a possible cause.
METHODS: The authors conducted a single-center, randomized, parallel-arm, double-masked, placebo-controlled study to examine the effect of daily multivitamin supplementation on the number and duration of RAS episodes. The authors randomly assigned 160 adults who had a validated history of at least three episodes of idiopathic minor RAS within the previous 12 months to one of two groups: the first group (n = 83) received a once-daily multivitamin containing 100 percent of the U.S. reference daily intake (RDI) of essential vitamins, and the second group (n = 77) received once-daily placebo for up to 365 days.
RESULTS: The results showed no significant difference in the mean number of new RAS episodes between the multivitamin (4.19 episodes) and placebo (4.60 episodes) arms during the study period (P = .69). The mean duration of new RAS episodes also was similar for the multivitamin (8.66 days) and placebo (8.99 days) arms (P = .60). Furthermore, the authors found no differences between the two arms with regard to mouth pain, normalcy of diet or compliance with the study medication regimen.
CONCLUSION: Daily multivitamin supplementation, with the RDI of essential vitamins, did not result in a reduction in the number or duration of RAS episodes.
CLINICAL IMPLICATIONS: Clinicians should not recommend multi-vitamin supplementation routinely as prophylaxis for RAS.
Authors:
Rajesh V Lalla; Linda E Choquette; Richard S Feinn; Harriet Zawistowski; Marie C Latortue; Edward T Kelly; Lorena Baccaglini
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Dental Association (1939)     Volume:  143     ISSN:  1943-4723     ISO Abbreviation:  J Am Dent Assoc     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-09-27     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7503060     Medline TA:  J Am Dent Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  D; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00527306
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antioxidants / therapeutic use
Ascorbic Acid / therapeutic use
Diet
Dietary Supplements*
Double-Blind Method
Female
Folic Acid / blood,  therapeutic use
Follow-Up Studies
Humans
Male
Middle Aged
Nutrition Policy
Patient Compliance
Placebos
Prospective Studies
Recurrence
Stomatitis, Aphthous / blood,  prevention & control*
Treatment Outcome
Vitamin A / therapeutic use
Vitamin B 12 / blood,  therapeutic use
Vitamin B Complex / therapeutic use
Vitamin D / therapeutic use
Vitamin E / therapeutic use
Vitamins / therapeutic use*
Young Adult
Grant Support
ID/Acronym/Agency:
K23 DE016946/DE/NIDCR NIH HHS; K23DE016946/DE/NIDCR NIH HHS; M01 RR006192/RR/NCRR NIH HHS; M01R006192//PHS HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Placebos; 0/Vitamins; 11103-57-4/Vitamin A; 12001-76-2/Vitamin B Complex; 1406-16-2/Vitamin D; 1406-18-4/Vitamin E; 935E97BOY8/Folic Acid; P6YC3EG204/Vitamin B 12; PQ6CK8PD0R/Ascorbic Acid
Comments/Corrections
Comment In:
Evid Based Dent. 2013 Mar;14(1):26   [PMID:  23579307 ]
J Evid Based Dent Pract. 2013 Mar;13(1):27-8   [PMID:  23481013 ]

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