| Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial. | |
| | |
MedLine Citation:
|
PMID: 22467697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a painful condition of unknown etiology, affecting more than 2.5 billion people worldwide. Vitamin deficiencies have been implicated as a possible cause. METHODS: The authors conducted a single-center, randomized, parallel-arm, double-masked, placebo-controlled study to examine the effect of daily multivitamin supplementation on the number and duration of RAS episodes. The authors randomly assigned 160 adults who had a validated history of at least three episodes of idiopathic minor RAS within the previous 12 months to one of two groups: the first group (n = 83) received a once-daily multivitamin containing 100 percent of the U.S. reference daily intake (RDI) of essential vitamins, and the second group (n = 77) received once-daily placebo for up to 365 days. RESULTS: The results showed no significant difference in the mean number of new RAS episodes between the multivitamin (4.19 episodes) and placebo (4.60 episodes) arms during the study period (P = .69). The mean duration of new RAS episodes also was similar for the multivitamin (8.66 days) and placebo (8.99 days) arms (P = .60). Furthermore, the authors found no differences between the two arms with regard to mouth pain, normalcy of diet or compliance with the study medication regimen. CONCLUSION: Daily multivitamin supplementation, with the RDI of essential vitamins, did not result in a reduction in the number or duration of RAS episodes. CLINICAL IMPLICATIONS: Clinicians should not recommend multi-vitamin supplementation routinely as prophylaxis for RAS. |
| | |
Authors:
|
Rajesh V Lalla; Linda E Choquette; Richard S Feinn; Harriet Zawistowski; Marie C Latortue; Edward T Kelly; Lorena Baccaglini |
Related Documents
:
|
18504337 - Antipsychotic therapy and short-term serious events in older adults with dementia. 17336767 - The long term--maximising potential for rehabilitation in patients with schizophrenia. 14728087 - Maintaining symptom control: review of ziprasidone long-term efficacy data. 12897637 - The impact of prolactin elevation with antipsychotic medications on subjective quality ... 21269707 - Depression and midlife: are we overpathologising the menopause? 19687157 - Diagnosing vasovagal syncope based on quantitative history-taking: validation of the ca... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American Dental Association (1939) Volume: 143 ISSN: 1943-4723 ISO Abbreviation: J Am Dent Assoc Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-04-02 Completed Date: 2012-09-27 Revised Date: 2013-05-22 |
Medline Journal Info:
|
Nlm Unique ID: 7503060 Medline TA: J Am Dent Assoc Country: United States |
Other Details:
|
Languages: eng Pagination: 370-6 Citation Subset: D; IM |
Affiliation:
|
Section of Oral Medicine, University of Connecticut Health Center, Farmington, Conn. 06030-1605, USA. lalla@uchc.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00527306 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Antioxidants / therapeutic use Ascorbic Acid / therapeutic use Diet Dietary Supplements* Double-Blind Method Female Folic Acid / blood, therapeutic use Follow-Up Studies Humans Male Middle Aged Nutrition Policy Patient Compliance Placebos Prospective Studies Recurrence Stomatitis, Aphthous / blood, prevention & control* Treatment Outcome Vitamin A / therapeutic use Vitamin B 12 / blood, therapeutic use Vitamin B Complex / therapeutic use Vitamin D / therapeutic use Vitamin E / therapeutic use Vitamins / therapeutic use* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
K23DE016946/DE/NIDCR NIH HHS; M01R006192//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Placebos; 0/Vitamins; 11103-57-4/Vitamin A; 12001-76-2/Vitamin B Complex; 1406-16-2/Vitamin D; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
| Comments/Corrections | |
Comment In:
|
J Evid Based Dent Pract. 2013 Mar;13(1):27-8
[PMID:
23481013
]
Evid Based Dent. 2013 Mar;14(1):26 [PMID: 23579307 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coronectomy: A surgical option for impacted third molars in close proximity to the inferior alveolar...
Next Document: Dentin caries activity in early occlusal lesions selected to receive operative treatment: Findings f...