Document Detail

Multivariate evaluation of factors influencing the performance of a formic acid biosensor for use in air monitoring.
MedLine Citation:
PMID:  11763083     Owner:  NLM     Status:  MEDLINE    
A formic acid biosensor for air monitoring has been evaluated using chemometric methods. Using experimental design eleven factors that could influence the performance of the biosensor were examined. The response matrices consisted of six parameters (steady state currents at three different formic acid concentrations and response rates during changes in formic acid concentrations) describing the performance of the biosensor. The data were evaluated using a combination of principal component analysis (PCA) and multiple linear regression (MLR). To confirm the conclusions from the PCA-MLR partial least squares (PLS) was also used. The most important factor for the biosensor performance was found to be the enzyme concentration. Using the information from the chemometric analyses the optimum operation conditions for the biosensor were determined. The steady state currents were increased by 18-30% and the initial two response rates increased by 47-89% compared with a biosensor that had not been optimised.
K J Sandström; R Carlson; A L Sunesson; J O Levin; A P Turner
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Analyst     Volume:  126     ISSN:  0003-2654     ISO Abbreviation:  Analyst     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  2008-14     Citation Subset:  IM    
Programme for Chemical Exposure Assessment, National Institute for Working Life, Umeå, Sweden.
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MeSH Terms
Air Pollutants, Occupational / analysis*
Biosensing Techniques*
Formic Acids*
Multivariate Analysis
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Formic Acids; 64-18-6/formic acid

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