Document Detail


Multivariate data reduction by principal components, with application to neurological scoring instruments.
MedLine Citation:
PMID:  2074446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Principal components analysis is widely used as a practical tool for the analysis of multivariate data. The aim of this analysis is to reduce the dimensionality of a multivariate data set to the smallest number of meaningful and independent dimensions. The analysis can also provide interpretable linear functions of the original measured variables that may serve as valuable indices of variation. A brief introduction to principal components analysis is given herein, followed by an examination of a particular set of multivariate data accruing from a study of acute brain injuries in a pediatric population, in which severity of brain injury had been assessed with the Glasgow Coma Scale (CGS). Principal components analysis reveals that the GCS sum score is a particularly inefficient summarizer of information in this cohort. The determination of an objective weighting of measured variables, as provided through principal components analysis, is essential in the construction of meaningful neurological scoring instruments.
Authors:
J A Koziol; W Hacke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurology     Volume:  237     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  461-4     Citation Subset:  IM    
Affiliation:
Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, CA 92037.
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MeSH Terms
Descriptor/Qualifier:
Coma / classification*,  physiopathology
Data Interpretation, Statistical
Glasgow Coma Scale*
Humans
Multivariate Analysis
Grant Support
ID/Acronym/Agency:
CA41582/CA/NCI NIH HHS; RR00833/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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