Document Detail

Multivariate analysis of risk factors of hematoma expansion in spontaneous intracerebral hemorrhage.
MedLine Citation:
PMID:  18054613     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We focused on the cause of hematoma expansion after admission because the volume of hematoma after S-ICH plays a crucial role in the cause of mortality and morbidity. METHODS: In a retrospective review, 51 patients with hematoma expansion of S-ICH were identified among 880 cases of S-ICH treated between 2001 and May 2006. We divided cases into 2 groups according to the time of hematoma expansion. An enlargement of hematoma within 2 weeks after hospitalization was categorized as the acute stage group and after 2 weeks was categorized as the chronic stage group. Spontaneous intracerebral hemorrhage without hematoma expansion group (100 cases) had been consecutively selected as a control group. We analyzed the risk factors of hematoma expansion in patients with S-ICH especially in the acute stage group. RESULTS: Fifty-one of 880 patients had the enlargement of hematoma (5.8%). Forty-three (84%) of 51 cases were acutely developed and 8 cases (16%) were developed chronically. On univariate analysis there were significant differences in BP within the initial 48 hours (P < .0001), GOS (P < .0001), and previously taking anticoagulant agents (P = .0053). Especially the difference in SBP and DBP within 48 hours between groups was 19 (11%) and 13 mm Hg (14%), respectively. The DBP within the initial 24 hours had a meaningful odds ratio (1.06) on logistic regression analysis. CONCLUSION: A reduction of BP by 15% (SBP < or =140 mm Hg, DBP < or =80 mm Hg) is necessary at acute stage in S-ICH.
Jae Kwan Lim; Hyung Sik Hwang; Byung Moon Cho; Ho Kook Lee; Sung Ki Ahn; Sae Moon Oh; Sun Kil Choi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  69     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-02-27     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-5; discussion 45     Citation Subset:  IM    
Department of Neurosurgery, College of Medicine, Hallym University, Seoul 150-030, South Korea.
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MeSH Terms
Anticoagulants / adverse effects
Blood Pressure / physiology
Cerebral Hemorrhage / etiology,  pathology*
Glasgow Outcome Scale
Hematoma / etiology,  pathology*
Logistic Models
Middle Aged
Odds Ratio
Retrospective Studies
Risk Factors
Time Factors
Reg. No./Substance:

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