Document Detail

Multivariate analysis results of radiotherapy for laryngeal cancer.
MedLine Citation:
PMID:  8407309     Owner:  NLM     Status:  MEDLINE    
We assess the impact of radiotherapy in the treatment of laryngeal cancer and evaluate the value of the standard dose (linear quadratic plus time model) and other variables to predict tumor control and survival. Between 1972 and 1989, 80 patients with laryngeal cancer received comprehensive radiotherapy. Patients with stage I laryngeal glottic cancer (T1-N0-M0) were excluded from this study. Mean follow-up was 15 months (range 4 to 181). The mean age was 64.8 years (range 40 to 92). Standard dose varied from 32.65 to 81.81 Gy (mean 66.78). The 5-year overall survival and tumor-specific survival rates were 44.9 +/- 5.8% and 51.4 +/- 5.9%, respectively. Five-year local control and locoregional control rates were 66.4 +/- 5.7% and 61.9 +/- 5.8%, respectively. Multivariate analysis showed that local control was significantly predicted by T stage (p = .032), but not by standard dose (p = .906). Independently significant factors predicting tumor-specific survival included stage (p = .006), site (p = .019), and age (p = .001). Local control and survival were significantly predicted by the TNM-staging classification. The standard dose did not predict local recurrence or survival.
E Cano; J Flickinger; J Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Head & neck     Volume:  15     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:    1993 Sep-Oct
Date Detail:
Created Date:  1993-11-05     Completed Date:  1993-11-05     Revised Date:  2006-10-05    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-8     Citation Subset:  IM    
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pennsylvania.
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MeSH Terms
Age Factors
Aged, 80 and over
Carcinoma, Squamous Cell / pathology,  radiotherapy*,  secondary
Cobalt Radioisotopes / adverse effects,  therapeutic use
Follow-Up Studies
Laryngeal Neoplasms / pathology,  radiotherapy*
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Neoplasm Staging
Proportional Hazards Models
Radiotherapy Dosage
Radiotherapy, High-Energy / adverse effects
Survival Rate
Treatment Failure
Reg. No./Substance:
0/Cobalt Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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