| Multivariate analysis results of radiotherapy for laryngeal cancer. | |
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MedLine Citation:
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PMID: 8407309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assess the impact of radiotherapy in the treatment of laryngeal cancer and evaluate the value of the standard dose (linear quadratic plus time model) and other variables to predict tumor control and survival. Between 1972 and 1989, 80 patients with laryngeal cancer received comprehensive radiotherapy. Patients with stage I laryngeal glottic cancer (T1-N0-M0) were excluded from this study. Mean follow-up was 15 months (range 4 to 181). The mean age was 64.8 years (range 40 to 92). Standard dose varied from 32.65 to 81.81 Gy (mean 66.78). The 5-year overall survival and tumor-specific survival rates were 44.9 +/- 5.8% and 51.4 +/- 5.9%, respectively. Five-year local control and locoregional control rates were 66.4 +/- 5.7% and 61.9 +/- 5.8%, respectively. Multivariate analysis showed that local control was significantly predicted by T stage (p = .032), but not by standard dose (p = .906). Independently significant factors predicting tumor-specific survival included stage (p = .006), site (p = .019), and age (p = .001). Local control and survival were significantly predicted by the TNM-staging classification. The standard dose did not predict local recurrence or survival. |
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Authors:
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E Cano; J Flickinger; J Johnson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Head & neck Volume: 15 ISSN: 1043-3074 ISO Abbreviation: Head Neck Publication Date: 1993 Sep-Oct |
Date Detail:
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Created Date: 1993-11-05 Completed Date: 1993-11-05 Revised Date: 2006-10-05 |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 382-8 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pennsylvania. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Carcinoma, Squamous Cell / pathology, radiotherapy*, secondary Cobalt Radioisotopes / adverse effects, therapeutic use Female Follow-Up Studies Humans Laryngeal Neoplasms / pathology, radiotherapy* Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Neoplasm Staging Proportional Hazards Models Radiotherapy Dosage Radiotherapy, High-Energy / adverse effects Survival Rate Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Cobalt Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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