Document Detail


Multivariate analysis of factors associated with early-onset segmental and nonsegmental vitiligo: a prospective observational study of 213 patients.
MedLine Citation:
PMID:  21410675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although mixed forms have been described recently, segmental (SV) and nonsegmental vitiligo (NSV) are considered as clinically distinct. However, limited epidemiological data are available to help distinguish associated factors, and recent genome-wide association studies have been restricted to NSV. The higher prevalence of SV in children is helpful when comparing the two major presentations of the disease.
OBJECTIVE: To compare factors associated with SV and NSV, especially for markers of autoimmunity or autoinflammation.
METHODS: We conducted a single-centre prospective observational study in patients aged 17 years or under with a confirmed diagnosis of SV or NSV at the vitiligo clinic between 1 January 2006 and 1 July 2010. The Vitiligo European Task Force questionnaire was completed for each patient, and thyroid function and antithyroid antibodies were screened if not obtained in the previous year. Other forms of vitiligo (focal, mucosal, not classifiable) were excluded.
RESULTS: A total of 213 children were included, 142 with NSV, 59 with SV and 12 with mixed vitiligo. There was no significant statistical difference for sex or age at onset between patients with SV and NSV. Halo naevi were significantly more frequent in NSV than in SV [odds ratio (OR) 7·58, P < 0·01). Patients with NSV more frequently had a positive family history of vitiligo (OR 2·25, P=0·02) and a marked familial autoimmunity background (OR 2·22, P = 0·01).
CONCLUSIONS: Our study clearly shows that features of inflammation (pruritus)/autoimmunity (halo naevi, thyroid antibodies) are strongly linked to NSV, together with a familial background of vitiligo and autoimmunity.
Authors:
K Ezzedine; A Diallo; C Léauté-Labrèze; D Mossalayi; Y Gauthier; S Bouchtnei; M Cario-André; J Seneschal; F Boralevi; T Jouary; A Taieb
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Publication Detail:
Type:  Journal Article     Date:  2011-06-02
Journal Detail:
Title:  The British journal of dermatology     Volume:  165     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-28     Completed Date:  2011-09-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Age of Onset
Autoimmune Diseases / immunology,  pathology
Child
Child, Preschool
Cohort Studies
Female
Humans
Infant
Male
Multivariate Analysis
Prospective Studies
Vitiligo / immunology,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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