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Multivariate analysis of factors associated with early onset segmental and non-segmental Vitiligo: a prospective observational study of 213 patients.
MedLine Citation:
PMID:  21410675     Owner:  NLM     Status:  Publisher    
Background:  Although mixed forms have been recently described, segmental (SV) and nonsegmental vitiligo (NSV) are considered as clinically distinct. However, limited epidemiological data is available to help distinguishing associated factors, and recent genomewide association studies have been restricted to NSV. The higher prevalence of SV in children is convenient to compare the two major presentations of the disease. Objective:  To compare factors associated with segmental and non-segmental vitiligo, especially for markers of autoimmunity or autoinflammation.. Patients and methods:  We conducted a single-center prospective observational study in patients aged 17 and less with a confirmed diagnosis of SV or NSV at the vitiligo clinic between January 1(st) , 2006 and July 1(st) , 2010. The Vitiligo European Task Force questionnaire was informed for each patient and thyroid function as well as anti-thyroid antibodies were screened if not obtained in the previous year. Other forms of vitiligo (focal, mucosal, not classifiable) were excluded. Results:  A total of 213 children were included, 142 with NSV, 59 with SV and 12 with mixed vitiligo. There was no significant statistical difference for sex, age of onset between SV and NSV patients. Halo nevi were significantly more frequent in NSV than in SV (OR: 7.58, p<0.01). Patients with NSV had more frequently a positive family history of vitiligo (OR: 2.25, p=0.02) and a marked familial autoimmunity background (OR: 2.22, p=0.01). Conclusions:  Our study clearly shown that features of inflammation (pruritus)/autoimmunity (halo nevi, thyroid antibodies) are strongly linked to NSV together with a familial background of vitiligo and autoimmunity.
K Ezzedine; A Diallo; C Léauté-Labrèze; D Mossalayi; Y Gauthier; S Bouchtnei; M Cario-André; J Seneschal; F Boralevi; T Jouary; A Taieb
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-17
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Department of Dermatology and National Centre for Rare Skin Disorders, CHU St-André, Bordeaux, France.
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