Document Detail

Multivariate analysis of aminoglycoside levels in hemodialysis patients.
MedLine Citation:
PMID:  2721288     Owner:  NLM     Status:  MEDLINE    
Multivariate discriminant analysis was performed on data for 50 consecutive hemodialysis patients who had received aminoglycoside treatment because of severe bacterial infections. The 10 of the 60 clinical parameters considered to be most important were survival of patients (28/50 patients), success of treatment (27/50 patients), acute or chronic renal failure (15 vs. 35), age (54 +/- 17 years), creatinine level (675 +/- 298 mumol/l), artificial ventilation (21/50 patients), need for catecholamines (19/50 patients), continuous arteriovenous hemofiltration (9/50 patients), duration of therapy (12 +/- 8 days) as well as aminoglycoside peak (7.5 +/- 2.7 mg/l) and trough levels (3.6 +/- 1.3 mg/l). The 4 of the 10 parameters investigated by multivariate analysis significantly contributing to survival of patients were clinical success of aminoglycoside treatment (p = 0.0001), no need for catecholamines (p = 0.0001), duration of dosage (p = 0.003) and aminoglycoside peak levels (p = 0.009).
U Kunzendorf; F Keller; G Walz; H Haller; G Offermann; K Borner; H Lode
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemotherapy     Volume:  35     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-27     Completed Date:  1989-06-27     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Freie Universität, Klinikum Steglitz, Berlin.
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MeSH Terms
Aged, 80 and over
Aminoglycosides / blood*,  pharmacokinetics
Kidney Failure, Chronic / blood
Middle Aged
Renal Dialysis*
Statistics as Topic
Reg. No./Substance:

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