Document Detail


Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone.
MedLine Citation:
PMID:  22145464     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIMS: All screening programmes in the UK use a primary thyroid stimulating hormone (TSH) screen for congenital hypothyroidism. Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to determine the factors affecting screening neonatal TSH levels.
METHODS: We conducted a retrospective analysis of blood spot screening TSH levels of all infants screened at a single regional screening laboratory.
RESULTS: There were 6498 infants screened during a 12-week period. Screening TSH level showed negative correlation with gestational age and birth weight. Multiple linear regression analysis revealed low birth weight as the only independent factor affecting screening TSH level.
CONCLUSIONS: Low birth weight infants appear to be at risk of thyroidal dysfunction. Our study showed that there were clinically significant but weak correlation between higher screening TSH levels and low birth weight. The clinical importance of these findings requires larger prospective studies to further elucidate the relevance of these factors affecting TSH screening levels.
Authors:
Sze May Ng; Sze Choong Wong; Fauzia Paize; Elavazhagan Chakkarapani; Paul Newland; David Isherwood; Mohammed Didi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  24     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  727-32     Citation Subset:  IM    
Affiliation:
Department of Women's and Children's Health, University of Liverpool, Liverpool, UK. may.ng@nhs.net
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