Document Detail


Multivariate Markov chain analysis of the probability of pregnancy in infertile couples undergoing assisted reproduction.
MedLine Citation:
PMID:  11756370     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Estimating the probability of pregnancy leading to delivery and the influence of clinical factors on that probability is of fundamental importance in the treatment counselling of infertile couples. A variety of statistical techniques have been used to analyse fertility data, many borrowed from survival analysis. METHODS AND RESULTS: We propose an alternative method of analysis which is based on a discrete time Markov chain approach, with states 'pregnancy (leading to a delivery)', 'not pregnant', and 'censored' and in which the transition probabilities are dependent both on the clinical characteristics of the patient and the treatment given. CONCLUSIONS: We believe that the method of analysis presented here may be preferable to standard analyses in that it better reflects the clinical situation, it is a truly discrete time analysis applied to a discrete time situation, it explicitly models the censoring process (a process which in itself provides information of interest to the physician) and can be readily extended to a variety of clinical situations.
Authors:
Joseph McDonnell; Angelique J Goverde; Frans F H Rutten; Jan P W Vermeiden
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  17     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-6     Citation Subset:  IM    
Affiliation:
Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands. mcdonnell@bmg.eur.nl
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Female
Fertilization in Vitro
Humans
Infertility / therapy*
Male
Markov Chains*
Pregnancy
Regression Analysis
Reproductive Techniques*
Treatment Outcome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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