Document Detail


Multivalent sialic acid conjugates inhibit adenovirus type 37 from binding to and infecting human corneal epithelial cells.
MedLine Citation:
PMID:  17014916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenovirus type 37 is one of the main causative agents of epidemic keratoconjunctivitis. In a series of publications, we have reported that this virus uses sialic acid as a cellular receptor. Here we demonstrate in vitro that on a molar basis, multivalent sialic acid conjugated to human serum albumin prevents adenovirus type 37 from binding to and infecting human corneal epithelial cells 1000-fold more efficiently than monosaccharidic sialic acid. We also demonstrate that the extraordinary inhibitory effect of multivalent sialic acid is due to the ability of this compound to aggregate virions. We conclude that multivalent sialic acid may be a potential new antiviral drug, for use in the treatment of epidemic keratoconjunctivitis caused by the adenoviruses that use sialic acid as cellular receptor.
Authors:
Susanne M C Johansson; Emma C Nilsson; Mikael Elofsson; Nina Ahlskog; Jan Kihlberg; Niklas Arnberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-05
Journal Detail:
Title:  Antiviral research     Volume:  73     ISSN:  0166-3542     ISO Abbreviation:  Antiviral Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  92-100     Citation Subset:  IM    
Affiliation:
Organic Chemistry, Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adenoviridae Infections / prevention & control*,  virology
Adenoviruses, Human / metabolism,  pathogenicity*
Cells, Cultured
Conjunctivitis, Viral / prevention & control*,  virology
Epithelium, Corneal / cytology,  virology*
Humans
N-Acetylneuraminic Acid / analogs & derivatives*,  chemistry,  pharmacology*
Oligosaccharides / chemistry,  pharmacology
Serum Albumin / chemistry,  pharmacology
Chemical
Reg. No./Substance:
0/Oligosaccharides; 0/Serum Albumin; 131-48-6/N-Acetylneuraminic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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