Document Detail


Multivalent catanionic GalCer analogs derived from first generation dendrimeric phosphonic acids.
MedLine Citation:
PMID:  19942442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis and characterization of a new series of catanionic multivalent analogs of GalCer is described. These systems are based on phosphonic acid terminated dendrimers and N-hexadecylamino lactitol moieties. Despite important structural differences that affect the dendrimers' outer-shell, these supramolecular assemblies showed a fairly comparable anti-HIV-1 activity. All compounds have submicromolar IC(50) in a cell-based HIV-infection model but also a high general cytotoxicity.
Authors:
Alexandra P?rez-Anes; Cristina Stefaniu; Christine Moog; Jean-Pierre Majoral; Muriel Blanzat; C?dric-Olivier Turrin; Anne-Marie Caminade; Isabelle Rico-Lattes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-03
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  18     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 Route de Narbonne, F-31077 Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / chemical synthesis,  chemistry*,  pharmacology*
Cell Line
Cell Survival
Dendrimers / chemical synthesis,  chemistry,  pharmacology
Galactosylceramides / chemical synthesis,  chemistry*,  pharmacology*
HIV Infections / drug therapy*
HIV-1 / drug effects*
Humans
Microbial Sensitivity Tests
Phosphonic Acids / chemical synthesis,  chemistry,  pharmacology
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Dendrimers; 0/Galactosylceramides; 0/Phosphonic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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