| Multivalent catanionic GalCer analogs derived from first generation dendrimeric phosphonic acids. | |
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MedLine Citation:
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PMID: 19942442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis and characterization of a new series of catanionic multivalent analogs of GalCer is described. These systems are based on phosphonic acid terminated dendrimers and N-hexadecylamino lactitol moieties. Despite important structural differences that affect the dendrimers' outer-shell, these supramolecular assemblies showed a fairly comparable anti-HIV-1 activity. All compounds have submicromolar IC(50) in a cell-based HIV-infection model but also a high general cytotoxicity. |
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Authors:
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Alexandra P?rez-Anes; Cristina Stefaniu; Christine Moog; Jean-Pierre Majoral; Muriel Blanzat; C?dric-Olivier Turrin; Anne-Marie Caminade; Isabelle Rico-Lattes |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-03 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 18 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 242-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 Route de Narbonne, F-31077 Toulouse, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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chemical synthesis,
chemistry*,
pharmacology* Cell Line Cell Survival Dendrimers / chemical synthesis, chemistry, pharmacology Galactosylceramides / chemical synthesis, chemistry*, pharmacology* HIV Infections / drug therapy* HIV-1 / drug effects* Humans Microbial Sensitivity Tests Phosphonic Acids / chemical synthesis, chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Dendrimers; 0/Galactosylceramides; 0/Phosphonic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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