| Multivalent, high-relaxivity MRI contrast agents using rigid cysteine-reactive gadolinium complexes. | |
| | |
MedLine Citation:
|
PMID: 21800868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
MRI contrast agents providing very high relaxivity values can be obtained through the attachment of multiple gadolinium(III) complexes to the interior surfaces of genome-free viral capsids. In previous studies, the contrast enhancement was predicted to depend on the rigidity of the linker attaching the MRI agents to the protein surface. To test this hypothesis, a new set of Gd-hydroxypyridonate based MRI agents was prepared and attached to genetically introduced cysteine residues through flexible and rigid linkers. Greater contrast enhancements were seen for MRI agents that were attached via rigid linkers, validating the design concept and outlining a path for future improvements of nanoscale MRI contrast agents. |
| | |
Authors:
|
Praveena D Garimella; Ankona Datta; Dante W Romanini; Kenneth N Raymond; Matthew B Francis |
Related Documents
:
|
19097208 - The tensor distribution function. 17398118 - Discordant white matter n-acetylasparate and diffusion mri measures suggest that chroni... 17069318 - Acoustic roles of the laryngeal cavity in vocal tract resonance. 20879278 - Symmetric positive-definite cartesian tensor orientation distribution functions (ct-odf). 7391308 - The use of three-dimensional computer display in the study of disk disease. 16410178 - Spin-lock mri with amplitude- and phase-modulated adiabatic waveforms: an mr simulation... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-08-26 |
Journal Detail:
|
Title: Journal of the American Chemical Society Volume: 133 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-09-14 Completed Date: 2012-01-10 Revised Date: 2012-01-19 |
Medline Journal Info:
|
Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
|
Languages: eng Pagination: 14704-9 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of California, Berkeley, California 94720-1460, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Capsid
/
chemistry Contrast Media / chemistry* Cysteine / chemistry* Gadolinium / chemistry* Magnetic Resonance Imaging / methods* Models, Molecular Organometallic Compounds / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
|
HL069832/HL/NHLBI NIH HHS; R01 HL069832-09/HL/NHLBI NIH HHS; R01 HL069832-11/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Organometallic Compounds; 0/gadolinium(III) 1,2-hydroxypyridonate; 52-90-4/Cysteine; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dimensionality Control of Vapochromic Hydrogen-Bonded Proton-Transfer Assemblies Composed of a Bis(h...
Next Document: Presence and Absence of Excited State Intramolecular Charge Transfer with the Six Isomers of Dicyano...