| Multisystem disorder of Punjabi children exhibiting spontaneous dermal and submucosal granulation tissue formation: LOGIC syndrome. | |
| | |
MedLine Citation:
|
PMID: 1342856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We describe a multisystem disease that affects children of Muslim families originating in the Punjab region of Pakistan and India. An altered cry due to vocal cord thickening, skin ulceration, nail abnormalities, and conjunctival scarring appear in the first few months of life. Progression and spread of the disease in these sites may be accompanied by involvement of other epithelial surfaces. The teeth may exhibit defective enamel formation. Histology reveals the formation of simple granulation tissue arising in the dermis and submucosa which become massively thickened and ulcerated. There is good evidence for an autosomal recessive gene defect, but the actual mechanism of the disease is not known. Medical and surgical therapy have been ineffective in altering the course of this devastating and usually fatal condition. We suggest the term LOGIC (laryngeal and ocular granulation tissue in children from the Indian subcontinent) for this newly established disease. |
| | |
Authors:
|
J R Ainsworth; G Shabbir; A F Spencer; F Cockburn |
Related Documents
:
|
7977246 - Gastric syphilis: a disease with multiple manifestations. 1822856 - Changes of mucosal endogenous prostacyclin level in human peptic ulcer disease. the rol... 3324326 - Scanning electron microscopy application in clinical research. 2914546 - Basal gastric acid secretion in nonulcer dyspepsia with or without duodenitis. 22424426 - Peripheral blood biomarkers in idiopathic pulmonary fibrosis. 3122506 - Human cystatins in normal and diseased tissues--a review. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical dysmorphology Volume: 1 ISSN: 0962-8827 ISO Abbreviation: Clin. Dysmorphol. Publication Date: 1992 Jan |
Date Detail:
|
Created Date: 1994-02-18 Completed Date: 1994-02-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9207893 Medline TA: Clin Dysmorphol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 3-15 Citation Subset: IM |
Affiliation:
|
Tennent Institute, Glasgow, Scotland, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Child, Preschool Conjunctival Diseases / ethnology, genetics Corneal Diseases / ethnology, genetics Female Granulation Tissue* Humans India Infant Islam Male Nail Diseases / ethnology, genetics Pakistan Skin Diseases* / ethnology, genetics Syndrome Ulcer / ethnology, genetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acrorenal syndrome: further observations.
Next Document: Encephalocele, radial defects, cardiac, gastrointestinal, anal, and renal anomalies: a new multiple ...