Document Detail


Multistate study of the epidemiology of clubfoot.
MedLine Citation:
PMID:  19697433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although clubfoot is a common birth defect, with a prevalence of approximately 1 per 1000 livebirths, the etiology of clubfoot remains largely unknown. Studies of the prevalence and risk factors for clubfoot in the United States have previously been limited to specific states. The purpose of this study was to pool data from several birth defects surveillance programs to better estimate the prevalence of clubfoot and investigate its risk factors. METHODS: The 10 population-based birth defects surveillance programs that participated in this study ascertained 6139 cases of clubfoot from 2001 through 2005. A random sample of 10 controls per case, matched on year and state of birth, was selected from birth certificates. Data on infant and maternal risk factors were collected from birth certificates. Prevalence was calculated by pooling the state-specific data. Conditional logistic regression was used to investigate the association between risk factors and clubfoot. RESULTS: The overall prevalence of clubfoot was 1.29 per 1000 livebirths; 1.38 among non-Hispanic whites, 1.30 among Hispanics, and 1.14 among non-Hispanic blacks or African Americans. Maternal age, parity, education, and marital status were significantly associated with clubfoot. Maternal smoking and diabetes also showed significant associations. Several of these observed associations were consistent between surveillance programs. CONCLUSIONS: We estimated the prevalence of clubfoot using data from several birth defects programs, representing one-quarter of all births in the United States. Our findings underline the importance of birth defects surveillance programs and their utility in monitoring population-based prevalence and investigating risk factors.
Authors:
Samantha E Parker; Cara T Mai; Matthew J Strickland; Richard S Olney; Russel Rickard; Lisa Marengo; Ying Wang; S Shahrukh Hashmi; Robert E Meyer;
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  85     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  897-904     Citation Subset:  IM    
Affiliation:
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. gwf5@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Certificates
Clubfoot / epidemiology*
Female
Humans
Logistic Models
Male
Population Surveillance
Prevalence
United States / epidemiology
Investigator
Investigator/Affiliation:
Russel Rickard / ; Paul Romitti / ; Matthew Strickland / ; Ying Wang / ; Robert Meyer / ; Laureane Alvelo-Maldonado / ; William Aries / ; David Law / ; Lisa Marengo / ; Melissa Baker /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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