Document Detail

Multislice spiral computed tomography to determine the effects of a recruitment maneuver in experimental lung injury.
MedLine Citation:
PMID:  16220208     Owner:  NLM     Status:  MEDLINE    
Although recruitment of atelectatic lung is a common aim in acute respiratory distress syndrome (ARDS), the effects of a recruitment maneuver have not been assessed quantitatively. By multislice spiral CT (MSCT), we analyzed the changes in lung volumes calculated from the changes in the CT values of hyperinflated (V(HYP)), normally (V(NORM)), poorly (V(POOR)) and nonaerated (V(NON)) lung in eight mechanically ventilated pigs with saline lavage-induced acute lung injury before and after a recruitment maneuver. This was compared to single slice analysis near the diaphragm. The increase in aerated lung was mainly for V(POOR) and the less in V(NORM). Total lung volume and intrathoracic gas increased. No differences were found for tidal volumes measured by spirometry or determined by CT. The inspiratory-expiratory volume differences were not different after the recruitment maneuver in V(NON) (from 62+/-18 ml to 43+/-26 ml, P = 0.114), and in V(NORM) (from 216+/-51 ml to 251+/-37 ml, P = 0.102). Single slice analysis significantly underestimated the increase in normally and poorly aerated lung. Quantitative analysis of lung volumes by whole lung MSCT revealed the increase of poorly aerated lung as the main mechanism of a standard recruitment maneuver. MSCT can provide additional information as compared to single slice CT.
Dietrich Henzler; Andreas H Mahnken; Joachim E Wildberger; Rolf Rossaint; Rolf W Günther; Ralf Kuhlen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-12
Journal Detail:
Title:  European radiology     Volume:  16     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-05     Completed Date:  2006-11-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1351-9     Citation Subset:  IM    
Anesthesiology Department, University Hospital, RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.
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MeSH Terms
Disease Models, Animal
Exhalation / physiology
Image Processing, Computer-Assisted / methods*
Inhalation / physiology
Lung / physiopathology*,  radiography
Pulmonary Atelectasis / physiopathology*,  radiography
Pulmonary Gas Exchange / physiology
Pulmonary Ventilation / physiology
Respiration, Artificial
Respiratory Distress Syndrome, Adult / physiopathology,  radiography
Tidal Volume / physiology
Tomography, Spiral Computed / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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