Document Detail

Multislice computed tomography for detection of patients with aortic valve stenosis and quantification of severity.
MedLine Citation:
PMID:  16580530     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to evaluate whether multislice computed tomography (MSCT) provides a reliable, noninvasive imaging modality for identification of patients with degenerative aortic valve stenosis (AS) by quantifying the aortic valve area (AVA) in comparison to the accepted diagnostic standard transthoracic echocardiography (TTE). BACKGROUND: Management of patients with degenerative AS is based on the severity of disease. The severity of AS in clinical practice is assessed by TTE and classified as mild, moderate, or severe according to the AVA. METHODS: Forty-six patients were examined with contrast-enhanced, electrocardiogram-gated, 16-row MSCT for the evaluation of the diagnostic accuracy. In 30 patients, quantification of the AVA with MSCT was compared to TTE using the continuity equation with Doppler velocity-time integral for calculation of the AVA. RESULTS: Sensitivity of MSCT for the identification of patients with degenerative AS was 100%, and the specificity was 93.7%. Thirty of 46 patients had AS determined by TTE. Quantification of AVA by MSCT (mean AVA = 0.94 cm2) in patients with AS showed a good correlation to TTE (r = 0.89; p < 0.001). Bland-Altman plot illustrated good intermodality agreement between the two methods (limits of agreement, 0.20; 0.29). CONCLUSIONS: Multislice computed tomography may provide an accurate, noninvasive imaging technique for detection of patients with AS and quantification of AVA.
Gudrun M Feuchtner; Wolfgang Dichtl; Guy J Friedrich; Mathias Frick; Hannes Alber; Thomas Schachner; Johannes Bonatti; Ammar Mallouhi; Thomas Frede; Otmar Pachinger; Dieter zur Nedden; Silvana Müller
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2006-03-20
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  47     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-03     Completed Date:  2006-05-26     Revised Date:  2007-01-11    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1410-7     Citation Subset:  AIM; IM    
Clinical Department of Radiology II, Innsbruck Medical University, Innsbruck, Austria.
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MeSH Terms
Aortic Valve / radiography,  ultrasonography
Aortic Valve Stenosis / radiography*,  ultrasonography
Middle Aged
Sensitivity and Specificity
Severity of Illness Index*
Tomography, X-Ray Computed / methods*,  standards
Comment In:
J Am Coll Cardiol. 2006 Dec 5;48(11):2353; author reply 2354   [PMID:  17161271 ]

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