Document Detail

Multisite study of infants with single-suture craniosynostosis: preliminary report of presurgery development.
MedLine Citation:
PMID:  16001919     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the cognitive and language development of untreated infants with a single suture craniosynostosis at time of diagnosis. DESIGN AND PARTICIPANTS: The study presents time 1 assessments on the first 100 infants with a single suture craniosynostosis (sagittal, metopic, unilateral coronal, and lambdoid) referred to the Infant Learning Project, a prospective, multisite, longitudinal study evaluating neurocognitive development. MAIN OUTCOME MEASURES: Infants were assessed with the mental (Mental Development Index [MDI]) and motor scales (Psychomotor Developmental Index [PDI]) of the Bayley Scales of Infant Development and the Preschool Language Scale receptive (PLS-AC) and expressive (PLS-EC) language scales. Mothers completed the Parenting Stress Inventory, a brief measure of intelligence (maternal IQ [MAT-IQ]), and provided information regarding family socioeconomic status (SES). RESULTS: As a group, infants scored significantly lower than the normative data on the MDI (91.9), PDI (83.5), PLS-AC (90.4), and PLS-EC (95.8), and the distribution of scores differed significantly from the expected distribution. MAT-IQ and SES were significantly correlated (.47, p < .01) with mothers of higher IQ coming from higher SES groups. Both MAT-IQ and SES were significantly negatively correlated with life stress events; however, neither MAT-IQ nor SES was correlated with any of the infant development scores. CONCLUSIONS: There may be a greater developmental risk for infants with a single suture craniosynostosis than previously believed. However, control group data will be necessary to confirm findings.
Kathleen A Kapp-Simon; Brian Leroux; Michael Cunningham; Matthew L Speltz
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  42     ISSN:  1055-6656     ISO Abbreviation:  Cleft Palate Craniofac. J.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-08     Completed Date:  2005-10-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-84     Citation Subset:  D; IM    
Department of Surgery, Northwestern University, Chicago, IL, USA.
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MeSH Terms
Child, Preschool
Craniosynostoses / complications*,  psychology*
Developmental Disabilities / diagnosis*,  etiology*
Language Development
Neuropsychological Tests / statistics & numerical data
Parenting / psychology
Prospective Studies
Psychomotor Performance
Stress, Psychological / diagnosis
Grant Support

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