Document Detail

Multisite, randomized, double-blind, placebo-controlled pilot clinical trial to evaluate the efficacy of buspirone as a relapse-prevention treatment for cocaine dependence.
MedLine Citation:
PMID:  24911028     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To evaluate the potential efficacy of buspirone as a relapse-prevention treatment for cocaine dependence.
METHOD: A randomized, double-blind, placebo-controlled, 16-week pilot trial was conducted at 6 clinical sites between August 2012 and June 2013. Adult crack cocaine users meeting DSM-IV-TR criteria for current cocaine dependence who were scheduled to be in inpatient/residential substance use disorder (SUD) treatment for 12-19 days when randomized and planning to enroll in local outpatient treatment through the end of the active treatment phase were randomized to buspirone titrated to 60 mg/d (n = 35) or placebo (n = 27). All participants received psychosocial treatment as usually provided by the SUD treatment programs in which they were enrolled. Outcome measures included maximum days of continuous cocaine abstinence (primary), proportion of cocaine use days, and days to first cocaine use during the outpatient treatment phase (study weeks 4-15) as assessed by self-report and urine drug screens.
RESULTS: There were no significant treatment effects on maximum continuous days of cocaine abstinence or days to first cocaine use. In the female participants (n = 23), there was a significant treatment-by-time interaction effect (χ²₁ = 15.26, P < .0001), reflecting an increase in cocaine use by those receiving buspirone, relative to placebo, early in the outpatient treatment phase. A similar effect was not detected in the male participants (n = 39; χ²₁ = 0.14, P = .70).
CONCLUSIONS: The results suggest that buspirone is unlikely to have a beneficial effect on preventing relapse to cocaine use and that buspirone for cocaine-dependent women may worsen their cocaine use outcomes.
TRIAL REGISTRATION: identifier: NCT01641159.
Theresa M Winhusen; Frankie Kropp; Robert Lindblad; Antoine Douaihy; Louise Haynes; Candace Hodgkins; Karen Chartier; Kyle M Kampman; Gaurav Sharma; Daniel F Lewis; Paul VanVeldhuisen; Jeff Theobald; Jeanine May; Gregory S Brigham
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-27
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  -     ISSN:  1555-2101     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Copyright 2014 Physicians Postgraduate Press, Inc.
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