Document Detail


Multisite intracerebral microdialysis to study the mechanism of L-DOPA induced dopamine and serotonin release in the parkinsonian brain.
MedLine Citation:
PMID:  23541043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
L-DOPA is currently one of the best medications for Parkinson's disease. It was assumed for several years that its benefits and side effects were related to the enhancement of dopamine release in the dopamine-depleted striatum. The use of intracerebral microdialysis combined with a pharmacological approach has led to the discovery that serotonergic neurons are responsible for dopamine release induced by L-DOPA. The subsequent use of multisite microdialysis has further revealed that L-DOPA-stimulated dopamine release is widespread and related to the serotonergic innervation. The present Review emphasizes the functional impact of extrastriatal release of dopamine induced by L-DOPA in both the therapeutic and side effects of L-DOPA.
Authors:
S Navailles; M Lagière; A Contini; P De Deurwaerdère
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-04-15
Journal Detail:
Title:  ACS chemical neuroscience     Volume:  4     ISSN:  1948-7193     ISO Abbreviation:  ACS Chem Neurosci     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-07-18     Completed Date:  2013-10-22     Revised Date:  2014-05-16    
Medline Journal Info:
Nlm Unique ID:  101525337     Medline TA:  ACS Chem Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiparkinson Agents / pharmacology*
Brain / drug effects*
Disease Models, Animal
Dopamine / secretion
Dopaminergic Neurons / drug effects*,  secretion
Dyskinesia, Drug-Induced
Levodopa / pharmacology*
Microdialysis
Neostriatum / drug effects
Parkinson Disease*
Rats
Serotonergic Neurons / drug effects*,  secretion
Serotonin / secretion
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 333DO1RDJY/Serotonin; 46627O600J/Levodopa; VTD58H1Z2X/Dopamine
Comments/Corrections

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