| Multisensory interactions in early evoked brain activity follow the principle of inverse effectiveness. | |
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MedLine Citation:
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PMID: 21497200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A major determinant of multisensory integration, derived from single-neuron studies in animals, is the principle of inverse effectiveness (IE), which describes the phenomenon whereby maximal multisensory response enhancements occur when the constituent unisensory stimuli are minimally effective in evoking responses. Human behavioral studies, which have shown that multisensory interactions are strongest when stimuli are low in intensity are in agreement with the IE principle, but the neurophysiologic basis for this finding is unknown. In this high-density electroencephalography (EEG) study, we examined effects of stimulus intensity on multisensory audiovisual processing in event-related potentials (ERPs) and response time (RT) facilitation in the bisensory redundant target effect (RTE). The RTE describes that RTs are faster for bisensory redundant targets than for the respective unisensory targets. Participants were presented with semantically meaningless unisensory auditory, unisensory visual and bisensory audiovisual stimuli of low, middle and high intensity, while they were instructed to make a speeded button response when a stimulus in either modality was presented. Behavioral data showed that the RTE exceeded predictions on the basis of probability summations of unisensory RTs, indicative of integrative multisensory processing, but only for low intensity stimuli. Paralleling this finding, multisensory interactions in short latency (40-60ms) ERPs with a left posterior and right anterior topography were found particularly for stimuli with low intensity. Our findings demonstrate that the IE principle is applicable to early multisensory processing in humans. |
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Authors:
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Daniel Senkowski; Dave Saint-Amour; Marion Höfle; John J Foxe |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-08 |
Journal Detail:
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Title: NeuroImage Volume: 56 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-31 Completed Date: 2011-10-17 Revised Date: 2013-02-13 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 2200-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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The Cognitive Neurophysiology Laboratory, Nathan S. Kline Institute for Psychiatric Research Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road Orangeburg, NY 10962, USA. dsenkows@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adult Auditory Perception / physiology* Brain / physiology* Electroencephalography Evoked Potentials / physiology* Humans Middle Aged Photic Stimulation Reaction Time / physiology Signal Processing, Computer-Assisted Visual Perception / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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263567//European Research Council; AG22696/AG/NIA NIH HHS; MH65350/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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