Document Detail


Multisensory interactions in early evoked brain activity follow the principle of inverse effectiveness.
MedLine Citation:
PMID:  21497200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A major determinant of multisensory integration, derived from single-neuron studies in animals, is the principle of inverse effectiveness (IE), which describes the phenomenon whereby maximal multisensory response enhancements occur when the constituent unisensory stimuli are minimally effective in evoking responses. Human behavioral studies, which have shown that multisensory interactions are strongest when stimuli are low in intensity are in agreement with the IE principle, but the neurophysiologic basis for this finding is unknown. In this high-density electroencephalography (EEG) study, we examined effects of stimulus intensity on multisensory audiovisual processing in event-related potentials (ERPs) and response time (RT) facilitation in the bisensory redundant target effect (RTE). The RTE describes that RTs are faster for bisensory redundant targets than for the respective unisensory targets. Participants were presented with semantically meaningless unisensory auditory, unisensory visual and bisensory audiovisual stimuli of low, middle and high intensity, while they were instructed to make a speeded button response when a stimulus in either modality was presented. Behavioral data showed that the RTE exceeded predictions on the basis of probability summations of unisensory RTs, indicative of integrative multisensory processing, but only for low intensity stimuli. Paralleling this finding, multisensory interactions in short latency (40-60ms) ERPs with a left posterior and right anterior topography were found particularly for stimuli with low intensity. Our findings demonstrate that the IE principle is applicable to early multisensory processing in humans.
Authors:
Daniel Senkowski; Dave Saint-Amour; Marion Höfle; John J Foxe
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-08
Journal Detail:
Title:  NeuroImage     Volume:  56     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-31     Completed Date:  2011-10-17     Revised Date:  2013-02-13    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2200-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
The Cognitive Neurophysiology Laboratory, Nathan S. Kline Institute for Psychiatric Research Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road Orangeburg, NY 10962, USA. dsenkows@uke.uni-hamburg.de
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adult
Auditory Perception / physiology*
Brain / physiology*
Electroencephalography
Evoked Potentials / physiology*
Humans
Middle Aged
Photic Stimulation
Reaction Time / physiology
Signal Processing, Computer-Assisted
Visual Perception / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
263567//European Research Council; AG22696/AG/NIA NIH HHS; MH65350/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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