Document Detail

Multiscale models of the hybrid palliation for hypoplastic left heart syndrome.
MedLine Citation:
PMID:  21092964     Owner:  NLM     Status:  MEDLINE    
A less-invasive procedure that combines interventional stent placement in the ductus arteriosus and surgical banding of the branch pulmonary arteries has been recently introduced in the treatment of the hypoplastic left heart syndrome (HLHS). The hemodynamic behaviour of this hybrid approach has not been examined before in a mathematical model. In this study, a mathematical model of the hybrid procedure for HLHS is described, applying a multiscale approach that couples 3D models of the area of the surgical operation and lumped parameter models of the remaining circulation. The effects of various degrees of pulmonary banding and different stent sizes inserted in the ductus arteriosus on pulmonary-systemic flow ratio, cardiac output and oxygen delivery were assessed. Computational results suggest that balanced systemic and pulmonary blood flow and optimal systemic oxygen delivery are sensitive to the degree of pulmonary arterial banding and not to the size of the ductal stent.
Chiara Corsini; Daria Cosentino; Giancarlo Pennati; Gabriele Dubini; Tain-Yen Hsia; Francesco Migliavacca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-18
Journal Detail:
Title:  Journal of biomechanics     Volume:  44     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-06-16     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  767-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Cardiac Output
Combined Modality Therapy
Computer Simulation
Coronary Circulation*
Hypoplastic Left Heart Syndrome / physiopathology*,  surgery*
Models, Cardiovascular*
Oxygen / metabolism*
Palliative Care / methods
Pulmonary Circulation*
Surgery, Computer-Assisted / methods
Treatment Outcome
Grant Support
FS/12/35/29566//British Heart Foundation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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