| Multiscale models of angiogenesis. | |
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MedLine Citation:
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PMID: 19349248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular disease, cancer, stroke, neurodegeneration, diabetes, inflammation, asthma, obesity, arthritis--the list of conditions that involve angiogenesis reads like main chapters in a book on pathology. Angiogenesis, the growth of capillaries from preexisting vessels, also occurs in normal physiology, in response to exercise or in the process of wound healing.Why and when is angiogenesis prevalent? What controls the process? How can we intelligently control it? These are the key questions driving researchers in fields as diverse as cell biology, oncology, cardiology, neurology, biomathematics, systems biology, and biomedical engineering. As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia. |
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Authors:
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Amina A Qutub; Feilim Mac Gabhann; Emmanouil D Karagiannis; Prakash Vempati; Aleksander S Popel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society Volume: 28 ISSN: 1937-4186 ISO Abbreviation: IEEE Eng Med Biol Mag Publication Date: 2009 Mar-Apr |
Date Detail:
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Created Date: 2009-04-07 Completed Date: 2009-08-14 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 8305985 Medline TA: IEEE Eng Med Biol Mag Country: United States |
Other Details:
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Languages: eng Pagination: 14-31 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA. aqutub@jhu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Computational Biology Computer Simulation Humans Hypoxia-Inducible Factor 1 / physiology Matrix Metalloproteinases / physiology Models, Cardiovascular* Neovascularization, Physiologic* Vascular Endothelial Growth Factor A / physiology |
| Grant Support | |
ID/Acronym/Agency:
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1F32HL085016-01/HL/NHLBI NIH HHS; F32 HL085016-03/HL/NHLBI NIH HHS; R00 HL093219-04/HL/NHLBI NIH HHS; R01 HL079653-04/HL/NHLBI NIH HHS; R01 HL101200-03/HL/NHLBI NIH HHS; R01 HL79653/HL/NHLBI NIH HHS; R33 HL087351/HL/NHLBI NIH HHS; R33 HL087351-03/HL/NHLBI NIH HHS; T32 HL7284/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1; 0/Vascular Endothelial Growth Factor A; EC 3.4.24.-/Matrix Metalloproteinases |
| Comments/Corrections | |
Erratum In:
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IEEE Eng Med Biol Mag. 2009 May-Jun;28(3):65 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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