Document Detail

Multiscale models of angiogenesis.
MedLine Citation:
PMID:  19349248     Owner:  NLM     Status:  MEDLINE    
Vascular disease, cancer, stroke, neurodegeneration, diabetes, inflammation, asthma, obesity, arthritis--the list of conditions that involve angiogenesis reads like main chapters in a book on pathology. Angiogenesis, the growth of capillaries from preexisting vessels, also occurs in normal physiology, in response to exercise or in the process of wound healing.Why and when is angiogenesis prevalent? What controls the process? How can we intelligently control it? These are the key questions driving researchers in fields as diverse as cell biology, oncology, cardiology, neurology, biomathematics, systems biology, and biomedical engineering. As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia.
Amina A Qutub; Feilim Mac Gabhann; Emmanouil D Karagiannis; Prakash Vempati; Aleksander S Popel
Related Documents :
10732898 - Stress doppler echocardiography for identification of susceptibility to high altitude p...
17317748 - Effects of hypoxia on diaphragmatic fatigue in highly trained athletes.
8221808 - Effect of acute systemic hypoxia on vascular permeability and leucocyte adherence in th...
7190938 - Increased fetal heart rate variability with acute hypoxia in chronically instrumented s...
24612898 - Association of exercise tolerance with effective arterial elastance obtained noninvasiv...
6896708 - Sequential effects of irradiation on the pulmonary surfactant system.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society     Volume:  28     ISSN:  1937-4186     ISO Abbreviation:  IEEE Eng Med Biol Mag     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-04-07     Completed Date:  2009-08-14     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8305985     Medline TA:  IEEE Eng Med Biol Mag     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-31     Citation Subset:  IM    
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Computational Biology
Computer Simulation
Hypoxia-Inducible Factor 1 / physiology
Matrix Metalloproteinases / physiology
Models, Cardiovascular*
Neovascularization, Physiologic*
Vascular Endothelial Growth Factor A / physiology
Grant Support
1F32HL085016-01/HL/NHLBI NIH HHS; F32 HL085016-03/HL/NHLBI NIH HHS; R00 HL093219-04/HL/NHLBI NIH HHS; R01 HL079653-04/HL/NHLBI NIH HHS; R01 HL101200-03/HL/NHLBI NIH HHS; R01 HL79653/HL/NHLBI NIH HHS; R33 HL087351/HL/NHLBI NIH HHS; R33 HL087351-03/HL/NHLBI NIH HHS; T32 HL7284/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1; 0/Vascular Endothelial Growth Factor A; EC 3.4.24.-/Matrix Metalloproteinases
Erratum In:
IEEE Eng Med Biol Mag. 2009 May-Jun;28(3):65

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multiscale modeling of biomedical, biological, and behavioral systems (Part 1).
Next Document:  Effect of red blood cells on platelet aggregation.