| Multiscale modeling of respiration. | |
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MedLine Citation:
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PMID: 19457732 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To distinguish mechanisms of impaired muscle oxygen delivery and oxidative metabolism in response to exercise, we need to evaluate how these factors affect muscle oxygen utilization (UO2m), which represents cellular respiration. During human or animal exercise experiments, direct in vivo measurement of UO2m is not feasible. Instead, pulmonary oxygen uptake (VO2p), which represents external respiration, is measured noninvasively at the mouth as an indirect indicator of metabolic processes that control cellular respiration in the working skeletal muscles [1]. Factors that contribute to the differences between the dynamic responses of UO2m and VO2p are circulatory dynamics [2], ventilation, oxygen stored in blood and muscle [3], and oxygen exchange across membranes. Therefore, using VO2p as an indicator of metabolic processes may be misleading in the presence of various disease states. In chronic obstructive pulmonary disease [4], diabetes [5], [6], or chronic heart failure [7], the dynamic response of VO2p to exercise is abnormally slow. In type 2 diabetes, low muscle blood flow may impair oxygen delivery to the working muscle. Clinically, these diseases may impair the mitochondrial oxidative metabolism as well [8]. |
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Authors:
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Haiying Zhou; Nicola Lai; Gerald Saidel; Marco Cabrera |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society Volume: 28 ISSN: 1937-4186 ISO Abbreviation: IEEE Eng Med Biol Mag Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-05-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305985 Medline TA: IEEE Eng Med Biol Mag Country: United States |
Other Details:
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Languages: eng Pagination: 34-40 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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