Document Detail


Multiprefectural spread of gastroenteritis outbreaks attributable to a single genogroup II norovirus strain from a tourist restaurant in Nagasaki, Japan.
MedLine Citation:
PMID:  15750067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of gastroenteritis outbreaks caused by noroviruses (NVs) among tourist groups from several prefectures was associated with eating a lunch prepared by a restaurant in Nagasaki City, Japan, on 18 and 19 November 2003. A retrospective cohort study was performed to estimate the magnitude of the outbreak and identify the source of infection. Epidemiological information was obtained through the local public health centers in the areas where the illness occurred. Stool and vomit specimens and food and environmental samples were analyzed by reverse transcription-PCR with genogroup-specific primers. Positive samples were sequenced and analyzed phylogenetically. Of 1,492 tourists who ate a lunch prepared by the restaurant during the 2-day period, 660 (44.2%) developed illness, with an average incubation time of 31.2 h. Whereas NVs were not detected in any food samples, identical sequences most closely related to the Mexico genotype of genogroup II NV were found in specimens from case patients, restaurant staff, and the kitchen table. Food handlers were concluded to be the source of the outbreak as a result of the contamination of several meals. The series of outbreaks described here exemplifies the role of tourism as a contemporary way to distribute a single infectious agent to multiple and geographically remote areas.
Authors:
Yoichi Hirakata; Kokichi Arisawa; Osamu Nishio; Osamu Nakagomi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  43     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-04-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1093-8     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Nagasaki University School of Medicine and Dentistry, Nagasaki 852-8501, Japan. hirakata@net.nagasaki-u.ac.jp
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY590117
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Base Sequence
Caliciviridae Infections / epidemiology*,  etiology
Child
Cohort Studies
Disease Outbreaks*
Food Microbiology*
Gastroenteritis / epidemiology*,  etiology
Genotype
Humans
Japan / epidemiology
Molecular Sequence Data
Norovirus / classification*,  genetics
Phylogeny
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Comments/Corrections

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