| Multipotent skin-derived precursors: from biology to clinical translation. | |
| | |
MedLine Citation:
|
PMID: 19896826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Skin-derived precursor cells (SKPs) are a novel population of neural crest-related precursor cells that can be isolated from embryonic and adult skin. SKPs are capable of generating neuronal, glial and mesodermal progeny. Fate mapping and microdissection experiments have demonstrated a neural crest origin of SKPs within defined niches in adult skin. The finding that SKP derivatives such as Schwann cells and neuronal cells have in vitro and in vivo function raises the possibility of SKPs being both an experimental and therapeutic resource for disease modelling and regenerative medicine. This review focuses on the increased understanding of the developmental and anatomical origins of SKPs and the biotechnological potential of these cells. |
| | |
Authors:
|
David P J Hunt; Colin Jahoda; Siddharthan Chandran |
Related Documents
:
|
12876276 - Dual function of slit2 in repulsion and enhanced migration of trunk, but not vagal, neu... 3503696 - Exogenous basement-membrane-like matrix stimulates adrenergic development in avian neur... 12700036 - Mechanisms of tumor cell invasion and angiogenesis in the central nervous system. 19876846 - Xenopus development from late gastrulation to feeding tadpole in simulated microgravity. 6981736 - Probing human malignant t cells with lectins: a comparison with their surface antigen p... 10025956 - Overexpression of the multidrug resistance-associated protein (mrp1) in human heavy met... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-11-05 |
Journal Detail:
|
Title: Current opinion in biotechnology Volume: 20 ISSN: 1879-0429 ISO Abbreviation: Curr. Opin. Biotechnol. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-11-25 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9100492 Medline TA: Curr Opin Biotechnol Country: England |
Other Details:
|
Languages: eng Pagination: 522-30 Citation Subset: IM |
Affiliation:
|
Euan MacDonald Centre, Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom. dpjh2@cam.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biotechnology Cell Differentiation Cell Separation Cell Transplantation* Humans Multipotent Stem Cells / cytology*, metabolism* Skin / cytology*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The minimum anticipated biological effect level (MABEL) for selection of first human dose in clinica...
Next Document: Strategies to restore motor functions after spinal cord injury.