| Multiplicity generates diversity in the retinoic acid signalling pathways. | |
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MedLine Citation:
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PMID: 1333659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complexity in the retinoid signalling system arises from a combination of several forms of retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric interactions between two families of nuclear retinoic acid receptors, and between nuclear retinoic acid receptors and other members of the nuclear receptor superfamily. Thus, a complex array of combinatorial effects is beginning to emerge which may account for the pleiotropic effects of retinoids. |
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Authors:
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M Leid; P Kastner; P Chambon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in biochemical sciences Volume: 17 ISSN: 0968-0004 ISO Abbreviation: Trends Biochem. Sci. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610674 Medline TA: Trends Biochem Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 427-33 Citation Subset: IM |
Affiliation:
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Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U/184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médecine, Strasbourg, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Carrier Proteins / physiology Gene Expression Regulation / physiology Humans Molecular Sequence Data Receptors, Retinoic Acid Regulatory Sequences, Nucleic Acid / physiology Signal Transduction / physiology* Transcription Factors / physiology Tretinoin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Receptors, Retinoic Acid; 0/Transcription Factors; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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