| Multiplicity of BMP signaling in skeletal development. | |
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MedLine Citation:
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PMID: 18083919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal development and homeostasis are complex processes involving systemic regulatory factors and local factors present in the bone microenvironment. Among these factors, bone morphogenetic proteins (BMPs) represent the major potent bone morphogens, which coordinate with other factors to exert their multiple functions by regulating cell condensation, as well as inducing chondrogenesis and osteogenesis. This article reviews the current status of BMP signaling in skeletal development, with focus on regulation at the level of the receptors. Crosstalk of the BMP pathway with other major signaling pathways is also summarized. |
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Authors:
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Xiangwei Wu; Weibin Shi; Xu Cao |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1116 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-12-17 Completed Date: 2008-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 29-49 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Development / physiology* Bone Morphogenetic Proteins / physiology* Humans Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Proteins |
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