Document Detail

Multiplexed RNA trafficking in oligodendrocytes and neurons.
MedLine Citation:
PMID:  18442491     Owner:  NLM     Status:  MEDLINE    
In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.
John H Carson; Yuanzheng Gao; Vedakumar Tatavarty; Mikhail K Levin; George Korza; Victor P Francone; Linda D Kosturko; Michael J Maggipinto; Elisa Barbarese
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-04-10
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1779     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-21     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  453-8     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / metabolism
Dendrites / metabolism
Neurons / metabolism*
Oligodendroglia / metabolism*
RNA / metabolism*
RNA Transport / physiology*
Grant Support
NS15190/NS/NINDS NIH HHS; NS19943/NS/NINDS NIH HHS; P41 RR013186/RR/NCRR NIH HHS; P41 RR013186-01A10004/RR/NCRR NIH HHS; P41 RR013186-020004/RR/NCRR NIH HHS; P41 RR013186-030004/RR/NCRR NIH HHS; P41 RR013186-040004/RR/NCRR NIH HHS; P41 RR013186-05/RR/NCRR NIH HHS; P41 RR013186-06/RR/NCRR NIH HHS; P41 RR013186-07/RR/NCRR NIH HHS; P41 RR013186-070008/RR/NCRR NIH HHS; P41 RR013186-08/RR/NCRR NIH HHS; P41 RR013186-080008/RR/NCRR NIH HHS; P41 RR013186-09/RR/NCRR NIH HHS; P41 RR013186-095988/RR/NCRR NIH HHS; P41 RR013186-10/RR/NCRR NIH HHS; P41 RR013186-108414/RR/NCRR NIH HHS; P41 RR013186-11/RR/NCRR NIH HHS; R01 NS019943/NS/NINDS NIH HHS; R01 NS019943-18/NS/NINDS NIH HHS; R01 NS019943-19/NS/NINDS NIH HHS; R01 NS019943-20/NS/NINDS NIH HHS; R01 NS019943-21A2/NS/NINDS NIH HHS; R01 NS019943-22/NS/NINDS NIH HHS; R56 NS015190-28A1/NS/NINDS NIH HHS; RG2843/RG/CSR NIH HHS; RR022624/RR/NCRR NIH HHS; RR13186/RR/NCRR NIH HHS; RR22232/RR/NCRR NIH HHS; S10 RR022624-01/RR/NCRR NIH HHS; U54 RR022232/RR/NCRR NIH HHS; U54 RR022232-01/RR/NCRR NIH HHS; U54 RR022232-010001/RR/NCRR NIH HHS; U54 RR022232-02/RR/NCRR NIH HHS; U54 RR022232-026280/RR/NCRR NIH HHS; U54 RR022232-03/RR/NCRR NIH HHS; U54 RR022232-035958/RR/NCRR NIH HHS; U54 RR022232-03S1/RR/NCRR NIH HHS; U54 RR022232-04/RR/NCRR NIH HHS
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