| Multiple vascular abnormalities and a paradoxical combination of vitamin B12 deficiency and thrombocytosis in a case with POEMS syndrome. | |
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MedLine Citation:
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PMID: 14673584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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POEMS/Crow-Fukase syndrome is a rare multisystem disorder associated with elevated vascular endothelial growth factor (VEGF), which clinically presents with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. We report a case of POEMS syndrome due to a gammopathy of undetermined significance with thrombocytosis, vitamin B(12) deficiency, highly elevated VEGF and in addition to glomeruloid angiomas two previously undescribed proliferative vascular lesions: a spinal arteriovenous fistula and a plexogenic pulmonary arteriopathy, which ultimately resulted in lethal pulmonary hypertension. We assume that the high VEGF levels caused the vascular abnormalities observed in our patient. |
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Authors:
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J Lewerenz; A Gocht; P H Hoeger; P von den Driesch; B Eckert; K Lamszus; H-J Stuerenburg; A Methner |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurology Volume: 250 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-15 Completed Date: 2004-02-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 1488-91 Citation Subset: IM |
Affiliation:
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Research Group Protective Signaling, Zentrum für Molekulare Neurobiologie and Department of Neurology, University Hospital Hamburg-Eppendorf, Germany. lewerenz@zmnh.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteriovenous Fistula / complications Female Humans Lung / blood supply, pathology Lung Diseases / complications, pathology POEMS Syndrome / blood, complications*, pathology, physiopathology Paraproteinemias / complications, physiopathology Spinal Cord / blood supply, pathology Spinal Cord Diseases / complications, pathology Thrombocytosis / complications* Vascular Diseases / complications*, pathology Vascular Endothelial Growth Factor A / blood Vitamin B 12 Deficiency / complications* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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