Document Detail


Multiple target antigens in pre-type I diabetes: implications for prediction.
MedLine Citation:
PMID:  2210619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prodromal phase of type I diabetes is characterized by the presence of a series of autoantibodies reacting with distinct autoantigens [anti-insulin, anti-64 kDa, islet cell antibodies ('antiganglioside')]. Anti-insulin autoantibodies appear to be unique in that the levels of such antibodies correlate with both the rate of progression to diabetes and age at which type I diabetes develops. With a combination of assays it is now possible to predict type I diabetes, allowing the design of research trials for diabetes prevention.
Authors:
R Ziegler; G S Eisenbarth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Hormone research     Volume:  33     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1990  
Date Detail:
Created Date:  1990-11-19     Completed Date:  1990-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  144-50; discussion 150-1     Citation Subset:  IM    
Affiliation:
Joslin Diabetes Center, New England Deaconess Hospital, Boston, Mass.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoantibodies / analysis
Autoantigens / immunology*
Diabetes Mellitus, Type 1 / diagnosis,  immunology*
Humans
Insulin / immunology
Islets of Langerhans / immunology
Grant Support
ID/Acronym/Agency:
DK32083/DK/NIDDK NIH HHS; DK36836/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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