Document Detail

Multiple systems organ failure: epidemiology and prognosis.
MedLine Citation:
PMID:  2650815     Owner:  NLM     Status:  MEDLINE    
This article reviews the basic epidemiologic and prognostic data for the syndrome of MSOF. When MSOF is defined as severe physiologic abnormalities, it occurs following a wide variety of diseases. The distinguishing feature of MSOF appears not to be the underlying etiology, but the uniform and frequently fatal outcome once it develops. This suggests that MSOF may represent a final common pathway to death rather than a clinical syndrome with a single underlying etiology. Regardless of cause, evaluating the incremental impact of new therapy on MSOF will be assisted by the adoption of uniform definitions as well as by the explicit measurement of severity of disease and calculation of individual probabilities of death.
W A Knaus; D P Wagner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care clinics     Volume:  5     ISSN:  0749-0704     ISO Abbreviation:  Crit Care Clin     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-07     Completed Date:  1989-06-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8507720     Medline TA:  Crit Care Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-32     Citation Subset:  IM    
George Washington University, Washington, DC.
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MeSH Terms
Cross-Sectional Studies
Life Support Care
Multiple Organ Failure / physiopathology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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