Document Detail

Multiple system atrophy manifested as dizziness and imbalance: a report of two cases.
MedLine Citation:
PMID:  12937917     Owner:  NLM     Status:  MEDLINE    
Multiple system atrophy (MSA) is a progressive neurodegenerative disease of undetermined origin that occasionally manifests as dizziness and imbalance. It is not often considered in clinical situations, especially not by neuro-otological consultants. Hence, we report our recent experience with two cases of MSA. One is that of a 62-year-old man with MSA with a predominant cerebellar feature, and the other is that of a 72-year-old man with MSA with a predominant parkinsonian feature. The results of the syncopic study correlated with orthostatic hypotension. The neuro-otological study in both patients revealed an abnormal eye tracking test, abnormal optokinetic nystagmus test and loss of visual suppression in the caloric nystagmus. These indicate that the central vestibular system, e.g., the cerebellum or brain stem, is affected by MSA, contributing to dizziness and imbalance. Therefore, diagnosis of MSA should be kept in mind by neuro-otological consultants when dealing with patients with dizziness and imbalance, especially when this is accompanied by orthostatic hypotension.
Shou-Ren Wang; Yi-Ho Young
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-03-12
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  260     ISSN:  0937-4477     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2004-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  404-7     Citation Subset:  IM    
Department of Otolaryngology, National Taiwan University Hospital, 1 Chang-te st., Taipei, Taiwan.
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MeSH Terms
Dizziness / etiology*,  physiopathology
Evoked Potentials, Auditory
Evoked Potentials, Auditory, Brain Stem
Magnetic Resonance Imaging
Middle Aged
Multiple System Atrophy / complications*,  diagnosis*,  physiopathology
Parkinsonian Disorders / etiology
Visual Pathways / physiopathology

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