| Multiple significant bortezomib-related toxicities in one patient: case report and literature review. | |
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MedLine Citation:
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PMID: 19525183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bortezomib has shown significant efficacy in the treatment of patients with relapsed multiple myeloma (MM) and is generally well tolerated. We report a 65-year-old male patient undergoing bortezomib therapy for MM who, with the addition of liposomal doxorubicin, presented with severe paralytic ileus, peripheral neuropathy, pruritic rash, and testicular pain. Each of these toxicities was temporally related to the bortezomib-based therapy and the administration of concomitant liposomal doxorubicin. Herein, we discuss the patient's course and briefly review the literature on these bortezomib combination-related toxicities. |
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Authors:
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Jeanette M Waller; John C Moretto; Kevin B Knopf |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical lymphoma & myeloma Volume: 9 ISSN: 1938-0712 ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-15 Completed Date: 2009-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256500 Medline TA: Clin Lymphoma Myeloma Country: United States |
Other Details:
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Languages: eng Pagination: E1-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, California Pacific Medical Center, San Francisco, CA 94115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use Boronic Acids / administration & dosage, adverse effects* Doxorubicin / administration & dosage, adverse effects* Humans Male Multiple Myeloma / drug therapy* Pain Peripheral Nervous System Diseases / complications, diagnosis Pruritus / complications, diagnosis Pyrazines / administration & dosage, adverse effects* Testis / pathology |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids; 0/Pyrazines; 0/bortezomib; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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