Document Detail

Multiple sclerosis - a vascular etiology?
MedLine Citation:
PMID:  21059535     Owner:  NLM     Status:  MEDLINE    
From the earliest pathological studies the perivenular localization of the demyelination in multiple sclerosis (MS) has been observed. It has recently been suggested that obstructions to venous flow or inadequate venous valves in the great veins in the neck, thorax and abdomen can cause damaging backflow into the cerebral and spinal cord circulations. Paolo Zamboni and colleagues have demonstrated abnormal venous circulation in some multiple sclerosis patients using non-invasive sonography and invasive venography. Furthermore, they have obtained apparent clinical improvement or stabilization by endovascular ballooning of points of obstruction in the great veins in some, at least temporarily. If non-invasive observations by others validate their initial observations of a significantly increased prevalence of venous obstructions in MS then trials of angioplasty/stenting would be justified in selected cases in view of the biological plausibility of the concept.
Bryce Weir
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  37     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  745-57     Citation Subset:  IM    
Department of Surgery, University of Chicago, Illinois, USA.
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MeSH Terms
Brain / pathology
Cerebral Veins / pathology*
Multiple Sclerosis / etiology*
Spinal Cord / pathology
Vascular Diseases / complications*
Comment In:
Can J Neurol Sci. 2010 Nov;37(6):716   [PMID:  21059529 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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