| Multiple sclerosis - a vascular etiology? | |
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MedLine Citation:
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PMID: 21059535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From the earliest pathological studies the perivenular localization of the demyelination in multiple sclerosis (MS) has been observed. It has recently been suggested that obstructions to venous flow or inadequate venous valves in the great veins in the neck, thorax and abdomen can cause damaging backflow into the cerebral and spinal cord circulations. Paolo Zamboni and colleagues have demonstrated abnormal venous circulation in some multiple sclerosis patients using non-invasive sonography and invasive venography. Furthermore, they have obtained apparent clinical improvement or stabilization by endovascular ballooning of points of obstruction in the great veins in some, at least temporarily. If non-invasive observations by others validate their initial observations of a significantly increased prevalence of venous obstructions in MS then trials of angioplasty/stenting would be justified in selected cases in view of the biological plausibility of the concept. |
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Authors:
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Bryce Weir |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 37 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 745-57 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Chicago, Illinois, USA. bkaweir@shaw.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology Cerebral Veins / pathology* Humans Multiple Sclerosis / etiology* Spinal Cord / pathology Vascular Diseases / complications* |
| Comments/Corrections | |
Comment In:
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Can J Neurol Sci. 2010 Nov;37(6):716
[PMID:
21059529
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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