| Multiple sclerosis relapses: a multivariable analysis of residual disability determinants. | |
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MedLine Citation:
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PMID: 18684216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recovery from multiple sclerosis (MS) relapses is variable. The factors influencing persistence of residual disability (RD) after a relapse are still to be thoroughly elucidated. AIMS OF STUDY: To assess RD after MS relapses and to define the factors associated with persistence of RD. METHODS: Data were retrospectively collected for all relapses in a population of relapsing-remitting MS patients during 3 years. Relapse severity and RD after 1 year were calculated on Expanded Disability Status Scale basis. A multivariable analysis for factors influencing RD and relapse severity was performed (variables: age, gender, disease duration, oligoclonal bands, relapse severity, monosymptomatic/polysymptomatic relapse, immunomodulating treatment, incomplete recovery at 1 month). RESULTS: A total of 174 relapses were assessed. RD after 1 year was observed in 54.5% of the relapses. Higher risk of RD was associated with occurrence of a severe relapse (P = 0.024). Incomplete recovery at 1 month was highly predictive of RD at 1 year (P < 0.0001). Risk of a severe relapse was associated with age <or= 30 years (P = 0.025) and inversely associated with the use of immunomodulating treatment (P = 0.006). CONCLUSIONS: Incomplete recovery at 1 month is a predictor of long-term persistence of RD. Higher relapse severity is associated with higher risk of RD. Risk of severe relapses is lower in patients treated with immunomodulating drugs. |
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Authors:
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M Vercellino; A Romagnolo; A Mattioda; S Masera; C Piacentino; A Merola; A Chiò; R Mutani; P Cavalla |
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Publication Detail:
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Type: Journal Article Date: 2008-08-05 |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 119 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 126-30 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, University of Turin, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Disability Evaluation Female Humans Logistic Models Male Middle Aged Models, Statistical Multiple Sclerosis, Relapsing-Remitting / diagnosis, physiopathology*, therapy Multivariate Analysis Oligoclonal Bands / cerebrospinal fluid Recurrence Retrospective Studies Risk Factors Severity of Illness Index Sex Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Oligoclonal Bands |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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