Document Detail


Multiple sclerosis relapses: a multivariable analysis of residual disability determinants.
MedLine Citation:
PMID:  18684216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recovery from multiple sclerosis (MS) relapses is variable. The factors influencing persistence of residual disability (RD) after a relapse are still to be thoroughly elucidated. AIMS OF STUDY: To assess RD after MS relapses and to define the factors associated with persistence of RD. METHODS: Data were retrospectively collected for all relapses in a population of relapsing-remitting MS patients during 3 years. Relapse severity and RD after 1 year were calculated on Expanded Disability Status Scale basis. A multivariable analysis for factors influencing RD and relapse severity was performed (variables: age, gender, disease duration, oligoclonal bands, relapse severity, monosymptomatic/polysymptomatic relapse, immunomodulating treatment, incomplete recovery at 1 month). RESULTS: A total of 174 relapses were assessed. RD after 1 year was observed in 54.5% of the relapses. Higher risk of RD was associated with occurrence of a severe relapse (P = 0.024). Incomplete recovery at 1 month was highly predictive of RD at 1 year (P < 0.0001). Risk of a severe relapse was associated with age <or= 30 years (P = 0.025) and inversely associated with the use of immunomodulating treatment (P = 0.006). CONCLUSIONS: Incomplete recovery at 1 month is a predictor of long-term persistence of RD. Higher relapse severity is associated with higher risk of RD. Risk of severe relapses is lower in patients treated with immunomodulating drugs.
Authors:
M Vercellino; A Romagnolo; A Mattioda; S Masera; C Piacentino; A Merola; A Chiò; R Mutani; P Cavalla
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Publication Detail:
Type:  Journal Article     Date:  2008-08-05
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  119     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, University of Turin, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Disability Evaluation
Female
Humans
Logistic Models
Male
Middle Aged
Models, Statistical
Multiple Sclerosis, Relapsing-Remitting / diagnosis,  physiopathology*,  therapy
Multivariate Analysis
Oligoclonal Bands / cerebrospinal fluid
Recurrence
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Factors
Young Adult
Chemical
Reg. No./Substance:
0/Oligoclonal Bands

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