Document Detail


Multiple sclerosis and prions.
MedLine Citation:
PMID:  8455467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The etiology of Multiple Sclerosis (MS) is unknown. Existing epidemiologic data suggests that MS can be an infectious disease. MS used to be classified as one of the 'slow infections'--many of these are caused by prions. Prions are small, proteinaceous, infectious particles--distinguished from viruses by the absence of intrinsic nucleic acids. In a contrast to the 'classic' prional diseases (Kuru, Scrapie or Creutzfeldt-Jacob Disease) that in CNS affect primarily neurons, the 'target' cell in MS is an oligodendrocyte. This may explain differences in disease presentation. This paper presents a pathophysiological model of MS based on the assumption that MS is a prional disease. Processes leading to the demyelination in Multiple Sclerosis seem also to involve lymphocytes, astrocytes and macrophages as well as the interferon system.
Authors:
S Wojtowicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  40     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-19     Completed Date:  1993-04-19     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  48-54     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202.
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MeSH Terms
Descriptor/Qualifier:
Genes, Viral
Humans
Models, Biological
Multiple Sclerosis / etiology*
Prion Diseases / etiology*
Prions / genetics,  metabolism,  pathogenicity
Chemical
Reg. No./Substance:
0/Prions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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