Document Detail

Multiple sclerosis and prions.
MedLine Citation:
PMID:  8455467     Owner:  NLM     Status:  MEDLINE    
The etiology of Multiple Sclerosis (MS) is unknown. Existing epidemiologic data suggests that MS can be an infectious disease. MS used to be classified as one of the 'slow infections'--many of these are caused by prions. Prions are small, proteinaceous, infectious particles--distinguished from viruses by the absence of intrinsic nucleic acids. In a contrast to the 'classic' prional diseases (Kuru, Scrapie or Creutzfeldt-Jacob Disease) that in CNS affect primarily neurons, the 'target' cell in MS is an oligodendrocyte. This may explain differences in disease presentation. This paper presents a pathophysiological model of MS based on the assumption that MS is a prional disease. Processes leading to the demyelination in Multiple Sclerosis seem also to involve lymphocytes, astrocytes and macrophages as well as the interferon system.
S Wojtowicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  40     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-19     Completed Date:  1993-04-19     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  48-54     Citation Subset:  IM    
Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202.
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MeSH Terms
Genes, Viral
Models, Biological
Multiple Sclerosis / etiology*
Prion Diseases / etiology*
Prions / genetics,  metabolism,  pathogenicity
Reg. No./Substance:

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