| Multiple sclerosis and prions. | |
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MedLine Citation:
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PMID: 8455467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The etiology of Multiple Sclerosis (MS) is unknown. Existing epidemiologic data suggests that MS can be an infectious disease. MS used to be classified as one of the 'slow infections'--many of these are caused by prions. Prions are small, proteinaceous, infectious particles--distinguished from viruses by the absence of intrinsic nucleic acids. In a contrast to the 'classic' prional diseases (Kuru, Scrapie or Creutzfeldt-Jacob Disease) that in CNS affect primarily neurons, the 'target' cell in MS is an oligodendrocyte. This may explain differences in disease presentation. This paper presents a pathophysiological model of MS based on the assumption that MS is a prional disease. Processes leading to the demyelination in Multiple Sclerosis seem also to involve lymphocytes, astrocytes and macrophages as well as the interferon system. |
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Authors:
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S Wojtowicz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 40 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-04-19 Completed Date: 1993-04-19 Revised Date: 2008-08-15 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 48-54 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Genes, Viral Humans Models, Biological Multiple Sclerosis / etiology* Prion Diseases / etiology* Prions / genetics, metabolism, pathogenicity |
| Chemical | |
Reg. No./Substance:
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0/Prions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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