Document Detail

Multiple sclerosis: new treatment trials and emerging therapeutic targets.
MedLine Citation:
PMID:  18451708     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review focuses on new therapeutic strategies in multiple sclerosis.
RECENT FINDINGS: The past decade has marked the advent of various new therapeutic strategies in multiple sclerosis. Whereas the current armamentarium of immunomodulatory medications has demonstrated beneficial effects on the disease, more effective and tolerable therapies are needed. Several novel therapeutic strategies in testing include oral therapies, monoclonal antibodies, symptomatic treatments as well as insights into neuroprotection and repair. Ways to build upon existing therapies are also under investigation, including early initiation of treatment and various combination regimens.
SUMMARY: New therapies, along with variations of currently available treatments, may prove more efficacious and tolerable than the available arsenal of treatments. Nevertheless, as the treatment horizon broadens, choosing first-line therapies will become more complicated, with greater influence of risk-to-benefit ratios in light of premature safety data. Patient's clinical, paraclinical and biomarker fingerprint profiles may help elucidate disease subtypes as well as response to therapy in an effort to individualize treatment choice. A complete discussion of all studies currently underway is beyond the scope of this review, which will highlight recent promising therapeutic strategies under investigation in the field of multiple sclerosis.
Tracy DeAngelis; Fred Lublin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  21     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-07-25     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-71     Citation Subset:  IM    
Department of Neurology, Mount Sinai School of Medicine New York, New York, USA.,
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MeSH Terms
Antibodies, Monoclonal / therapeutic use*
Clinical Trials as Topic
Immunotherapy / methods*
Multiple Sclerosis / immunology,  therapy*
Reg. No./Substance:
0/Antibodies, Monoclonal

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