| Multiple sclerosis and neurofibromatosis type 1: report of seven patients from Iran. | |
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MedLine Citation:
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PMID: 19692435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Co-occurrence of multiple sclerosis (MS) and neurofibromatosis type 1 (NF1) is rare. CASE REPORTS: In this study, we describe the clinical and neuroimaging features of seven patients with NF1 and MS. In our patients, six patients with MS were women, in all of them history of NF1 existed. Three of our patients had primary progressive, one had secondary progressive MS, and three relapsing-remitting MS. Optic neuritis as presenting symptoms was seen in three patients, and motor manifestation as presenting symptom was observed in three patients. The risk of having both NF1 and MS seemed to be higher than would be expected based on the prevalence rates of the two diseases in the general population. CONCLUSION: The findings of this study suggest a possible casual relationship between MS and NF1, indicating higher risk of MS among patients with NF1. |
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Authors:
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M Etemadifar; F Fatehi; M A Sahraian; A Borhanihaghighi; P M Ardestani; M Kaji-Esfahani; A H Maghzi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 15 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-20 Completed Date: 2009-10-30 Revised Date: 2011-01-26 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 1126-30 Citation Subset: IM |
Affiliation:
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Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / pathology Female Humans Iran / epidemiology Magnetic Resonance Imaging Male Multiple Sclerosis, Chronic Progressive / epidemiology*, immunology, pathology Neurofibromatosis 1 / epidemiology*, immunology, pathology Prevalence Risk Factors Young Adult |
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