Document Detail

Multiple sclerosis in Malaysia.
MedLine Citation:
PMID:  3369969     Owner:  NLM     Status:  MEDLINE    
Thirty consecutive patients from peninsular Malaysia with clinically definite multiple sclerosis were studied; 80% were ethnic Chinese, with a female-male ratio of 5:1. The average age at onset was 29.7 years, with one relapse average every 1.9 years. Optic-spinal recurrence was the most common clinical pattern of the disease, accounting for 63.3% (19/30) of the cases. All the patients had spinal cord involvement sometime during the course of the illness. The mortality was high at 36.7% (11/30), with an average duration of symptoms of 7.6 years. There was characteristic severe residual visual and motor disability. At the time of the last examination, 12 patients had bilateral optic atrophy with blindness or severe visual acuity impairment. Sixteen patients were bedridden or confined to a wheelchair. The severe motor disability reflected the severe spinal cord involvement. It was the main factor that accounted for the high mortality. The cerebral, cerebellar, and brain-stem involvements were, however, generally transient. None of the patients' had a family history of similar illness despite the average sibling size of six. There was no example of Devic's disease. The clinical pattern was closest to those patients who presented from Taiwan.
C T Tan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  45     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-23     Completed Date:  1988-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-7     Citation Subset:  AIM; IM    
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur.
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MeSH Terms
China / ethnology
Multiple Sclerosis / complications*,  epidemiology
Nervous System Diseases / etiology

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