Document Detail


Multiple sclerosis and autoimmune diseases: epidemiology and HLA-DR association in North-east Italy.
MedLine Citation:
PMID:  16502215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An autoimmune background is thought to characterize the families of multiple sclerosis (MS) patients, but disease patterns and HLA-DR association seem to vary considerably among different ethnic groups. We investigated the prevalence of autoimmune diseases in 245 MS patients and 245 age- and sex-matched normal controls (NC), originating from and living in North-east Italy, and their first degree relatives, using a case-control method. Further, HLA-DRB1 expression was analysed in MS and NC. The following significant findings were observed: 1) a significant excess of autoimmunity in first-degree relatives of MS patients (p = 0.000), 2) an association of MS with Type 1 diabetes mellitus (T1DM) (p = 0.02), 3) an increase in DR4 expression (namely DRB1*0401) in MS patients from families with multiple autoimmune pathology compared with reference MS patients (p=0.02) and NC (p=0.01). We conclude that the risk of autoimmune disease is higher in first-degree relatives of MS patients and that disease association and HLA-DR expression in North-east Italy differs from other geographic regions of Europe.
Authors:
Alice Laroni; Massimiliano Calabrese; Paola Perini; Maria Paola Albergoni; Federica Ranzato; Michela Tiberio; Leontino Battistin; Paolo Gallo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-06
Journal Detail:
Title:  Journal of neurology     Volume:  253     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-12-05     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  636-9     Citation Subset:  IM    
Affiliation:
Multiple Sclerosis Centre of the Veneto, Region, First Neurology Clinic-Dept. of Neurosciences, University of Padova, Via Giustiniani 5, 35128, Padova, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Autoimmune Diseases / epidemiology,  genetics
Autoimmunity*
Case-Control Studies
Chi-Square Distribution
Female
Genetic Predisposition to Disease*
HLA-DR Antigens / genetics*
Humans
Italy / epidemiology,  ethnology
Male
Middle Aged
Multiple Sclerosis / epidemiology*,  genetics*
Prevalence
Risk
Chemical
Reg. No./Substance:
0/HLA-DR Antigens

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