| Multiple sclerosis and autoimmune diseases: epidemiology and HLA-DR association in North-east Italy. | |
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MedLine Citation:
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PMID: 16502215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An autoimmune background is thought to characterize the families of multiple sclerosis (MS) patients, but disease patterns and HLA-DR association seem to vary considerably among different ethnic groups. We investigated the prevalence of autoimmune diseases in 245 MS patients and 245 age- and sex-matched normal controls (NC), originating from and living in North-east Italy, and their first degree relatives, using a case-control method. Further, HLA-DRB1 expression was analysed in MS and NC. The following significant findings were observed: 1) a significant excess of autoimmunity in first-degree relatives of MS patients (p = 0.000), 2) an association of MS with Type 1 diabetes mellitus (T1DM) (p = 0.02), 3) an increase in DR4 expression (namely DRB1*0401) in MS patients from families with multiple autoimmune pathology compared with reference MS patients (p=0.02) and NC (p=0.01). We conclude that the risk of autoimmune disease is higher in first-degree relatives of MS patients and that disease association and HLA-DR expression in North-east Italy differs from other geographic regions of Europe. |
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Authors:
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Alice Laroni; Massimiliano Calabrese; Paola Perini; Maria Paola Albergoni; Federica Ranzato; Michela Tiberio; Leontino Battistin; Paolo Gallo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-06 |
Journal Detail:
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Title: Journal of neurology Volume: 253 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-06-12 Completed Date: 2006-12-05 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 636-9 Citation Subset: IM |
Affiliation:
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Multiple Sclerosis Centre of the Veneto, Region, First Neurology Clinic-Dept. of Neurosciences, University of Padova, Via Giustiniani 5, 35128, Padova, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Autoimmune Diseases / epidemiology, genetics Autoimmunity* Case-Control Studies Chi-Square Distribution Female Genetic Predisposition to Disease* HLA-DR Antigens / genetics* Humans Italy / epidemiology, ethnology Male Middle Aged Multiple Sclerosis / epidemiology*, genetics* Prevalence Risk |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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