| Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. | |
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MedLine Citation:
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PMID: 2548084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-specific oncogene activations. Three targets for viral integration were identified: c-myb, c-myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated with different lymphoma phenotypes. The c-bic locus was a target for integration in one class of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late stages of tumor progression. |
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Authors:
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B E Clurman; W S Hayward |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular and cellular biology Volume: 9 ISSN: 0270-7306 ISO Abbreviation: Mol. Cell. Biol. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-09-21 Completed Date: 1989-09-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8109087 Medline TA: Mol Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2657-64 Citation Subset: IM |
Affiliation:
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Sloan-Kettering Institute for Cancer Research, New York, New York 10021. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avian Leukosis / genetics Avian leukosis virus / genetics, physiology* B-Lymphocytes / microbiology Chick Embryo Chickens Cloning, Molecular DNA Probes DNA, Neoplasm / genetics Gene Expression Regulation* Leukemia, Lymphocytic, Chronic, B-Cell / genetics*, microbiology Proto-Oncogenes* RNA, Messenger / genetics, isolation & purification RNA, Neoplasm / genetics Restriction Mapping |
| Grant Support | |
ID/Acronym/Agency:
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CA-16599/CA/NCI NIH HHS; CA-43250/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; 0/DNA, Neoplasm; 0/RNA, Messenger; 0/RNA, Neoplasm |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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