Document Detail


Multiple primary malignant tumors of upper gastrointestinal tract: a novel role of 18F-FDG PET/CT.
MedLine Citation:
PMID:  20712059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate the capacity of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) for detecting multiple primary cancer of upper gastrointestinal (UGI) tract.
METHODS: Fifteen patients (12 without cancer histories and 3 with histories of upper GI tract cancer) were investigated due to the suspicion of primary cancer of UGI tract on X-ray barium meal and CT scan. Subsequent whole body (18)F-FDG PET/CT scan was carried out for initial staging or restaging. All the patients were finally confirmed by endoscopic biopsy or surgery. The detection rate of multiple primary malignant cancers was calculated based on (18)F-FDG PET/CT and endoscopic examinations.
RESULTS: (18)F-FDG PET/CT scan was positive in 32 suspicious lesions, 30/32 were true positive primary lesions, and 2/32 were false positive. In 15 suspicious lesions with negative (18)F-FDG PET/CT scan, 12/15 were true negative and 3/15 were false negative. Among the 15 patients, 12 patients had 29 primary synchronous tumors confirmed by pathology, including 8 cases of esophageal cancers accompanied with gastric cancer and 4 of hypopharynx cancers with esophageal cancer. The other 3 patients had 4 new primary metachronous tumors, which were multiple primary esophageal cancers. PET/CT imaging detected local lymph node metastases in 11 patients. Both local lymph node metastases and distant metastases were detected in 4 patients. On a per-primary lesion basis, the sensitivity, specificity, accuracy, negative predictive value and positive predictive value of (18)F-FDG PET/CT for detecting multiple primary cancer of UGI tract were 90.9%, 85.7%, 89.4%, 80% and 93.7%, respectively.
CONCLUSION: The whole body (18)F-FDG PET/CT may play an important role in evaluating the multiple primary malignant tumors of UGI tract cancer.
Authors:
Long Sun; Ying Wan; Qin Lin; Yong-Hong Sun; Long Zhao; Zuo-Ming Luo; Hua Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-07     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3964-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Biopsy
China
Endoscopy, Gastrointestinal
False Negative Reactions
False Positive Reactions
Female
Fluorodeoxyglucose F18 / diagnostic use*
Gastrointestinal Neoplasms / pathology,  radiography*,  radionuclide imaging*
Humans
Lymph Nodes / radiography,  radionuclide imaging
Male
Middle Aged
Neoplasm Staging
Neoplasms, Multiple Primary / pathology,  radiography*,  radionuclide imaging*
Positron-Emission Tomography*
Predictive Value of Tests
Radiopharmaceuticals / diagnostic use*
Retrospective Studies
Tomography, X-Ray Computed*
Whole Body Imaging
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 0Z5B2CJX4D/Fluorodeoxyglucose F18
Comments/Corrections

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