Document Detail

Multiple premature beats triggered ventricular arrhythmias during pilsicainide infusion in a patient with inferior ST-segment elevation.
MedLine Citation:
PMID:  17201857     Owner:  NLM     Status:  MEDLINE    
A 17-year-old man was referred to our hospital for treatment of common paroxysmal atrial flutter. His electrocardiogram at rest showed subtle ST-segment elevation in leads II, III, and aV(F). Intravenous pilsicainide caused further ST-segment elevation in the inferior leads, new ST-segment depression in leads V2-V6, two distinct forms of premature ventricular complexes (PVCs) triggering short runs of polymorphic ventricular tachycardia (VT). An infusion of isoproterenol suppressed these arrhythmias and normalized the ST-segment. Pilsicainide may induce PVCs and polymorphic VT in atypical Brugada syndrome.
Masaomi Chinushi; Daisuke Izumi; Hiroshi Furushima; Hiroshi Watanabe; Yoshifusa Aizawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  29     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-04     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1445-8     Citation Subset:  IM    
School of Health Science, Niigata University School of Medicine, Niigata, Japan.
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MeSH Terms
Anti-Arrhythmia Agents / adverse effects*
Atrial Flutter / complications,  drug therapy
Infusions, Intravenous
Lidocaine / administration & dosage,  adverse effects,  analogs & derivatives*
Ventricular Fibrillation / chemically induced*,  diagnosis*
Ventricular Premature Complexes / chemically induced*,  diagnosis*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine; 88069-49-2/pilsicainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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