| Multiple paragangliomas in a pregnant patient with a succinate dehydrogenase B mutation. | |
| | |
MedLine Citation:
|
PMID: 21084781 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
In this case report, we document the clinical course, laboratory findings, and imaging findings of a 21-year-old pregnant woman with multiple paragangliomas due to a succinate dehydrogenase B (SDHB) mutation. We also review the literature on previously reported cases. The patient presented with nausea, palpitations, angina, and amenorrhea. Her blood pressure was 170/100 mm Hg and her beta-human chorionic gonadotropin was positive. Her blood pressure remained high despite phenoxybenzamine titration. A 24-hour urine analysis revealed elevated plasma metanephrines. Imaging was initially deferred due to early gestational age. After the patient terminated the pregnancy, magnetic resonance imaging revealed a left suprarenal mass, a mass at the aortic bifurcation, and a left periaortic mass. Her blood pressure was controlled on phenoxybenzamine and labetalol. The masses were excised. Pathology revealed paragangliomas. Genetic testing revealed mutation in the SDHB gene. One month later, her blood pressure was 122/86 mm Hg off of medication. Paraganglioma/pheochromocytoma should be suspected when hypertension occurs early in pregnancy. Genetic testing is important, as this may impact future offspring. |
| | |
Authors:
|
Sonali Ganguly; Shane LeBeau; Kim Pierce; Ramesh Ramanathan; Rose Salata |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Postgraduate medicine Volume: 122 ISSN: 1941-9260 ISO Abbreviation: Postgrad Med Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401147 Medline TA: Postgrad Med Country: United States |
Other Details:
|
Languages: eng Pagination: 46-50 Citation Subset: AIM; IM |
Affiliation:
|
Department of Endocrinology, Singapore General Hospital, Singapore. sonali.ganguly@sgh.com.sg |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Low agreement between the modified diet and renal disease formula and the Cockcroft-Gault formula fo...
Next Document: Erectile dysfunction may improve by blood pressure control in patients with high-risk hypertension.