Document Detail


Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis.
MedLine Citation:
PMID:  19301204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anti nuclear (ANA) immunomorphological patterns such as multiple nuclear dots (MND) and rim-like/membranous (RL/M) are considered highly specific but little sensitive for primary biliary cirrhosis (PBC) diagnosis. To evaluate frequency and clinical significance of MND and RL/M in PBC patients when investigated at the level of immunoglobulin G isotypes. MND and RL/M pattern have been tested in 141 PBC sera and 230 pathological controls using HEp-2 cells as substrate and anti- total IgG and individual IgG subclasses (IgG1, IgG2, IgG3, IgG4) as specific antisera. One hundred and fourteen of 141 (80%) PBC patients had RL/M or MND pattern when IgG subclasses were used as revealing reagents (vs. 34% when anti total IgG were used, p < 0.0001). The prevalent isotype was IgG1 for RL/M, and IgG2 for MND pattern. None of controls was positive. No clinical differences in terms of severity and outcome of disease have been observed in PBC patients positive for MND and RL/M when investigated with IgG isotypes. The research for RL/M and MND pattern at level of IgG isotype determines a wide gain in terms of sensitivity without a loss of specificity. In Italian PBC patients MND and RL/M pattern did not seem to characterize any subgroup of patients with a poorer prognosis.
Authors:
Paolo Muratori; Alessandro Granito; Silvia Ferri; Georgios Pappas; Umberto Volta; Rita Menichella; Francesco B Bianchi; Marco Lenzi; Luigi Muratori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Autoimmunity     Volume:  42     ISSN:  1607-842X     ISO Abbreviation:  Autoimmunity     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  England    
Other Details:
Languages:  eng     Pagination:  224-7     Citation Subset:  IM    
Affiliation:
Department of Clinical Medicine, Alma Mater Studiorum, University of Bologna, Italy. paolo.muratori3@unibo.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibodies, Antinuclear / blood,  immunology*
Autoantibodies / blood,  immunology
Humans
Immunoglobulin G / blood,  immunology
Immunoglobulin Isotypes / blood,  immunology*
Immunoglobulin M / blood
Liver Cirrhosis, Biliary / diagnosis,  immunology*
Middle Aged
Mitochondria / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantibodies; 0/Immunoglobulin G; 0/Immunoglobulin Isotypes; 0/Immunoglobulin M

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